课题基金 / 基金详情

DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH

DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
参与重链转换的 DNA 序列
批准号：
2395785
负责人：
Wesley A. Dunnick
金额：
$23.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-09-01 至 2002-07-31
来源：
https://reporter.nih.gov/project-details/2395785
关键词：
B lymphocyte CD40 molecule T lymphocyte gene mutation gene rearrangement genetic promoter element genetic regulatory element genetic transcription genetically modified animals immunoglobulin genes interleukin 4 laboratory mouse tissue /cell culture transfection

项目摘要

项目成果

Wesley A. Dunnick的其他基金

相关文献

中文摘要
翻译
描述：本实验的总体目标是理解
英文摘要
DESCRIPTION: The overall goal of the proposed experiments is to understand the cis-acting elements through which switch recombination is regulated. The investigator has established a transgenic mouse model that measures properly regulated germline transcription from the murine g1 gene. He has also prepared a line of transgenic mice that can undergo switch recombination to g1. He will investigate the function of the cis-acting elements in the g1 gene by further localization of the elements in transgenes, by analysis of their ability to interact with other promoters, by their deletion from the endogenous g1 gene and by studying the effect of mutations of the cis-acting elements on both germline transcription and switch recombination. He will also study the transcriptional regulation of the g2a gene, emphasizing both cis-acting elements in the g2a gene and in the heavy chain 3 regulatory region.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Normal and aberrant switch recombination to the murine alpha heavy chain gene
Normal and aberrant switch recombination to the murine alpha heavy chain gene
DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH