SMOKELESS TOBACCO--NICOTINE PATCH & SELF HELP TREATMENT

无烟烟草的使用对大约6人的健康构成严重威胁 数百万经常使用这种药物的人会导致各种癌症和其他疾病 健康问题。加州吸烟基线调查199o-1991年发现 加利福尼亚州北部的一个无烟烟草使用率较高的地区 在成年男性中为10.4%，而在 全州6%，全国6%。目前人们对此知之甚少 无烟烟草戒烟的有效方法。到目前为止，有 只发表了三项关于成人无烟戒烟的研究 干预措施。这些已发表的研究中没有一项检查使用 尼古丁替代疗法。 在这项研究中，我们建议进行一项随机实验，比较 自助材料加尼古丁贴片和自助的有效性 材料加安慰剂贴片，400名无烟烟草使用者。在这 双盲研究，受试者将通过电话进行筛选和面试 并从受过研究培训的药剂师那里获得材料和贴片 协议。所有受试者都将在收到通知前设定戒烟日期 并将提供电话支持/咨询 大约在他们设定的戒烟日期后一周。全部400无烟 烟草使用者将在基线、3个月、6个月和12个月以及唾液中进行评估 烟草使用状况的可替宁核查将在6个月后进行。 除了随机试验外，我们还建议研究一种通用的 通过以下途径选择的无烟烟草使用者的总体样本(N=150) 随机数字拨号电话访谈探索两者之间的差异 无烟烟草使用者和参与以下活动的使用者- 戒烟干预。样品将在基线和 间隔3、6和12个月。

Smokeless tobacco use is a serious health threat to the approximately 6 million regular users of the drug causing various cancers and other health problems. The California Baseline Smoking Survey 199O-1991 found a region in northern California which had a smokeless tobacco use rate of 10.4% among their adult males as compared to a 3.5% rate across the whole state and 6% nationally. Very little is currently known about effective methods of cessation for smokeless tobacco. To date there have been only three published studies of adult smokeless tobacco cessation interventions. None of these published studies has examined the use of nicotine replacement therapy. In this study we propose to conduct a randomized experiment comparing the effectiveness of self-help materials plus nicotine patch and self-help materials plus placebo patch with 400 smokeless tobacco users. In this double blind study, subjects will be screened and interviewed by phone and receive materials and patches from pharmacists trained in the study protocol. All subjects will set a quit date prior to receiving the intervention and will be provided with phone support/counseling approximately one week after their set quit date. All 400 smokeless tobacco users will be assessed at baseline,3, 6, and 12 months and saliva cotinine verification of tobacco use status will be done at 6 months. In addition to the randomized trial, we propose to study a general population sample (N=150) of smokeless tobacco users selected through random-digit dial telephone interviewing to explore differences between smokeless tobacco users in general and users who participate in the- cessation interventions. The sample will be measured at baseline and at 3, 6, and 12 month intervals.