INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTS

全关节置换术中的接口故障

• 批准号: 2732852
• 负责人: KENNETH A. MANN
• 金额: $ 11.63万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-15 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2732852
• 关键词: analytical method; arthroplasty; biomaterial interface interaction; biomechanics; hip prosthesis; mechanical stress

DESCRIPTION (Adapted from the Applicant's Abstract): Aseptic loosening continues to be a problem with total hip replacements. In cemented total hip replacement, mechanically induced loosening most often initiates at the stem-cement or cement-bone interface. And while it is widely accepted that a strong bone is desirable at the cement-bone interface, the optimal cement-metal interface is disputed for cemented femoral components. A research program is proposed to investigate: 1) the specific mechanical conditions under which the femoral stem-cement and cement-bone interfaces fail; 2) the manner in which interface failure contributes to mechanical loosening of cemented femoral hip components; and 3) the use of this information to "optimize" the locations and extent of stem-cement bonding to reduce the risk of implant failure. Here, "bonding" is used to describe any enhanced stem-cement interface (mechanically roughened or PMMA precoated), as compared to a smooth unbonded interface. It is the hypothesis of this work that the manner and extent of bonding of the stem-cement interface affects the overall failure (loosening) of the implant. It is further hypothesized that some "optimum" configuration, consisting of regions where the stem is bonded, and regions where the stem is unbonded, will result in a significant increase in the long-term performance of the implant.

描述（改编自申请人的摘要）：无菌松动 总髋关节置换率仍然是一个问题。 在胶结总数中 髋关节置换，机械诱导的放松最常在 茎水泥或水泥骨接口。 虽然被广泛接受 在水泥骨界面上需要坚固的骨头，最佳 水泥 - 金属界面对于水泥股骨成分有争议。 一个 提出了研究计划来调查：1）特定的机械 股骨水泥和水泥骨接口的条件 失败; 2）界面故障有助于机械的方式 松开胶结股骨髋关节成分； 3）使用此 信息以“优化”干燥的位置和范围 降低植入物衰竭的风险。 在这里，“结合”用于描述任何 增强的干果界界面（机械粗糙或PMMA预涂）， 与平滑的未键入界面相比。 这是这个假设 工作的工作方式和粘结界面的方式和程度 影响植入物的总体失败（松动）。 进一步 假设某些“最佳”配置，由区域组成 茎是粘合的，茎未构成的区域将导致 植入物的长期性能显着提高。