BMP SIGNALLING IN EYE AND KIDNEY DEVELOPMENT

BMP 信号在眼睛和肾脏发育中的作用

• 批准号: 2674008
• 负责人: ELIZABETH J ROBERTSON
• 金额: $ 26.86万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-09 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2674008
• 关键词: apoptosis; biological signal transduction; cell cycle; cell type; eye; gene targeting; histogenesis; kidney; laboratory mouse; organ culture; protein structure function; reporter genes; transforming growth factors

DESCRIPTION: Experiments are designed to gain further insight into BMP signalling pathways during organogenesis. Aim 1 is to evaluate contributions of BMP7 to cell proliferation, survival, and programmed cell death during eye and kidney development. Aim 2 is to describe further the ability of BMP7 to regulate inductive tissue interactions during eye and kidney development. Aim 3 is to examine potentially distinct and overlapping functional roles of divergent BMP family members during eye and kidney development.

实验旨在进一步了解BMP