KELOID TISSUE & HYPERTROPHIC SCAR: GENETICS, BIOTECHNOLOGY: MINORITY HLTH SKIN

我们研究的总体目标是确定细胞和 导致瘢痕疙瘩生长的分子机制。 设立主 来自瘢痕疙瘩和非瘢痕疙瘩组织的成纤维细胞培养物。 探讨 氨基酸转运至作为前体的脯氨酸的机制 增加瘢痕疙瘩中的胶原蛋白合成。 以确定是否特定 生长因子（TGF-α、TNF-α、FGF、BFGF、PDGF和EGF）和细胞因子 会通过调节氨基酸运输影响瘢痕疙瘩的生长， 基质蛋白如胶原蛋白和纤连蛋白的表达。 到 探讨抑癌基因p53、RB、CDD在胃癌中的作用。 瘢痕疙瘩 并结合PRC技术建立HLA分型 瘢痕疙瘩样本 为了实现这些目标，我们正在使用瘢痕疙瘩 从寻求我们服务的患者身上取下的组织， 不可接受和/或有症状的瘢痕疙瘩l

The overall aim of our studies is to determine the cellular and molecular mechanisms that lead to keloid growth. Establish primary fibroblast cultures from keloid and non-keloid tissues. Investigate mechanisms of the amino acid transport to proline as a precursor of increased collagen synthesis in keloids. To determine if specific growth factors (TGF-", TNF-", "FGF, BFGF, PDGF and EGF) and cytokines will influence keloid growth, by regulating amino acid transport, & expression of matrix proteins such as collagen(s)and fibronectin. To investigate the role of the tumor suppressor genes p53, RB, CDD in keloids. And establish HLA typing in combination with PRC technology for keloid samples. To accomplish these goals we are using keloid tissue from patients who seek our services for removal of cosmetically unacceptable and/or symptomatic keloidsl