KELOID TISSUE & HYPERTROPHIC SCAR: GENETICS, BIOTECHNOLOGY: MINORITY HLTH SKIN

我们研究的总体目标是确定细胞和 导致瘢痕疙瘩生长的分子机制。建立主服务器 瘢痕疙瘩和非瘢痕疙瘩组织的成纤维细胞培养。调查 氨基酸作为前驱物质转运到Pro的机制 瘢痕疙瘩中胶原合成增加。确定是否特定 生长因子(转化生长因子、肿瘤坏死因子、成纤维细胞生长因子、碱性成纤维细胞生长因子、血小板衍生生长因子和表皮生长因子)和细胞因子 会通过调节氨基酸的运输来影响瘢痕疙瘩的生长。 胶原(S)、纤维连接蛋白等基质蛋白的表达。至 探讨抑癌基因P53、Rb、CDD在乳腺癌中的作用 瘢痕疙瘩。结合PRC技术建立人类白细胞抗原分型方法 用于瘢痕疙瘩样本。为了达到这些目标，我们正在使用瘢痕疙瘩 来自寻求我们服务的患者的组织，用于整容切除 不可接受和/或有症状的瘢痕疙瘩

The overall aim of our studies is to determine the cellular and molecular mechanisms that lead to keloid growth. Establish primary fibroblast cultures from keloid and non-keloid tissues. Investigate mechanisms of the amino acid transport to proline as a precursor of increased collagen synthesis in keloids. To determine if specific growth factors (TGF-", TNF-", "FGF, BFGF, PDGF and EGF) and cytokines will influence keloid growth, by regulating amino acid transport, & expression of matrix proteins such as collagen(s)and fibronectin. To investigate the role of the tumor suppressor genes p53, RB, CDD in keloids. And establish HLA typing in combination with PRC technology for keloid samples. To accomplish these goals we are using keloid tissue from patients who seek our services for removal of cosmetically unacceptable and/or symptomatic keloidsl