KELOID TISSUE & HYPERTROPHIC SCAR: GENETICS, BIOTECHNOLOGY: MINORITY HLTH SKIN

瘢痕疙瘩组织

• 批准号: 6121446
• 负责人: PAUL A KELLY
• 金额: $ 11万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121446
• 关键词: African American; biotechnology; cardiovascular system; child (0-11); endocrine gland /system; epidemiology; female; genetics; genome; hematology; human subject; male; minority institution research support; skin

The overall aim of our studies is to determine the cellular and molecular mechanisms that lead to keloid growth. Establish primary fibroblast cultures from keloid and non-keloid tissues. Investigate mechanisms of the amino acid transport to proline as a precursor of increased collagen synthesis in keloids. To determine if specific growth factors (TGF-", TNF-", "FGF, BFGF, PDGF and EGF) and cytokines will influence keloid growth, by regulating amino acid transport, & expression of matrix proteins such as collagen(s)and fibronectin. To investigate the role of the tumor suppressor genes p53, RB, CDD in keloids. And establish HLA typing in combination with PRC technology for keloid samples. To accomplish these goals we are using keloid tissue from patients who seek our services for removal of cosmetically unacceptable and/or symptomatic keloidsl

我们研究的总体目标是确定细胞和 导致疤痕疙瘩生长的分子机制。 建立初级 来自疤痕疙瘩和非疤痕疙瘩组织的成纤维细胞培养物。 调查 氨基酸转运至脯氨酸作为前体的机制 疤痕疙瘩中胶原蛋白的合成增加。 确定是否具体 生长因子（TGF-”、TNF-”、“FGF、BFGF、PDGF 和 EGF）和细胞因子 通过调节氨基酸运输来影响疤痕疙瘩的生长，& 基质蛋白如胶原蛋白和纤连蛋白的表达。 到 研究抑癌基因p53、RB、CDD在肿瘤中的作用 疤痕疙瘩。 并结合PRC技术建立HLA分型 用于疤痕疙瘩样品。 为了实现这些目标，我们正在使用疤痕疙瘩 来自寻求我们去除美容服务的患者的组织 不可接受的和/或有症状的疤痕疙瘩