NORMAL METABOLISM AND ANATOMY OF BASAL FOREBRAIN IN MAN

描述(改编自申请人的摘要)：一个大型数据集 将使用高分辨率联合配准的PET/MRI图像来显影 研究基底前脑的解剖学和图像处理方法。 70名经过严格筛查的健康成年人(每十年5名男性和5名女性 年龄在20岁到90岁之间)在执行一系列词汇学习任务时被拍摄成图像。 将对另外30个人进行成像，以增加统计能力。 使用GE 2048头部专用扫描仪(4.5 mm分辨率)进行扫描 在平面上，以18F-脱氧葡萄糖为示踪剂)。日冕 将1.2 mm厚的MRI图像与PET图像进行配准。这个 研究人员将重点研究纹状体、苍白球和无名质， 特别注意腹侧纹状体(伏隔核、纹状体 桥入无名质)和腹侧苍白球，因为它们 MRI研究较少(相对于背侧尾状核和壳核) 在人类身上。一种新的3D地标变形方法--薄板样条线，将对齐 并将所有图像的大小调整到相同的坐标。调查员将开发出 基底前脑解剖标志和变异图像的图集 将对象与统一坐标对齐。他将检验以下假设 与年龄相关的萎缩和新陈代谢减少的区域更大 运动皮质(后、背壳核和苍白球)多于区域 与边缘系统相连(如腹侧纹状体和苍白球)。他会的 扩展现有的相关方法以了解地形 额叶-基底前脑连接性及其相似性评价 已知的非人类灵长类动物的地形和人类代谢的相关模式。 基底前脑的互补性大小关系 背侧纹状体(壳至苍白球)和腹侧的结构 (伏隔核到腹侧苍白球)系统将被探索以测试 假设纹状体面积较小的个体将表现出更大的 这些区域发送到的结构中的大小或功能活动 抑制性投射。最后，调查员将测试现实 基础前脑的幻影提供了准确的经验测量 PET分辨率和尸检冠状甲酚紫和 Weigert染色脑片建立冠状切片位置坐标 并评估它们的变异。

DESCRIPTION (Adapted from applicant's abstract): A large data set of high-resolution coregistered PET/MRI images will be used to develop anatomical and image-processing methods to study the basal forebrain. Seventy rigorously screened healthy adults (5 men and 5 women in each decade from ages 20-90) were imaged while performing a serial verbal learning task. Thirty additional individuals will be imaged to increase statistical power. Scans were obtained with a GE 2048 head-dedicated scanner (4.5-mm resolution in plane, 2.5-3.5M counts) using 18F-deoxyglucose as the tracer. Coronal MRI images (1.2mm thick slices) were coregistered to the PET images. The investigator will focus on the striatum, pallidum and substantia innominata, with special attention to the ventral striatum (nucleus accumbens, striatal bridges into the substantia innominata) and ventral pallidum because they have been less studied (relative to the dorsal caudate and putamen) with MRI in man. A new 3D landmark-morphing method, thin-plate splines, will align and size all images to the same coordinates. The investigator will develop an atlas of basal forebrain anatomical landmarks and variance images for aligning subjects to uniform coordinates. He will test the hypothesis of greater age-related shrinkage and metabolic decrease in areas linked to motor cortex (posterior and dorsal putamen and globus pallidus) than areas linked to the limbic system (e.g., ventral striatum and pallidum). He will extend current correlational methods for understanding the topography of frontal-basal forebrain connectivity and evaluate the similarities between known nonhuman primate topography and human metabolic correlational pattern. Reciprocal compensatory size relationships between basal forebrain structures in the dorsal striatal (putamen to globus pallidus) and ventral (nucleus accumbens to ventral pallidum) systems will be explored to test the hypothesis that individuals with smaller striatal areas will show greater size or functional activity in the structures to which these areas send inhibitory projections. Lastly, the investigator will test realistic phantoms of the basal forebrain to provide accurate empirical measures of PET resolution and examine coronal postmortem cresyl violet and Weigert-stained brain slices to develop coronal slice location coordinates and assess their variation.