M-CPP PET SCANNING IN ALCOHOLISM: EFFECTS OF SERTRALINE

M-CPP PET 扫描在酗酒中的应用：舍曲林的影响

• 批准号: 7718112
• 负责人: MONTE Stuart BUCHSBAUM
• 金额: $ 4.57万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718112
• 关键词: Alcohol abuse; Alcoholism; Brain; Chemicals; Clinical; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Measurement; Patients; Pharmaceutical Preparations; Publications; Purpose; Research; Research Personnel; Resources; Scanning; Selective Serotonin Reuptake Inhibitor; Serotonin; Sertraline; Source; Subgroup; System; United States National Institutes of Health; Work; Zoloft; problem drinker

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A significant body of preclinial and clinical work demonstrates the involvement of the serotonin system in alcoholism. Recent publication of two successful clinical trials of serotonin reuptake inhibitors (e.g. sertraline or Zoloft) holds signicicant promise for the field. Both of these studies depended upon the division of their alcoholic patients into subgroups to reveal the medications' efficacy. The purpose of this study is two-fold. First, to determine the effect of a chemical called serotonin in the brains of people with alcohol abuse problems and to see if measurements of serotonin functioning can help predict who will respond successfully to treatment. Second, to study whether the medication Sertraline, which works with the brain's serotonin system, is effective in the treatment of people with alcohol abuse problems.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 大量的临床前和临床研究表明，5-羟色胺系统参与了酒精中毒。最近发表的两项成功的5-羟色胺再摄取抑制剂(如舍曲林或左洛复)临床试验在该领域具有重要的前景。这两项研究都依赖于将酗酒患者分成不同的亚组来揭示药物的疗效。 这项研究的目的有两个。首先，确定一种名为5-羟色胺的化学物质在有酒精滥用问题的人的大脑中的影响，并看看对5-羟色胺功能的测量是否有助于预测谁会对治疗做出成功反应。其次，研究与大脑5-羟色胺系统一起工作的药物舍曲林是否对有酗酒问题的人有效。