ACOUSTIC COMMUNICATION AND HORMONE CONTROL

声音通讯和激素控制

• 批准号: 2468272
• 负责人: Walter Wilczynski
• 金额: $ 12.47万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-10 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2468272
• 关键词: Anura; Rana; animal communication behavior; behavioral /social science research tag; blood chemistry; brain mapping; gonadotropin releasing factor; hormone regulation /control mechanism; immunocytochemistry; neural plasticity; neuroendocrine system; perfusion; preoptic areas; radionuclide double label; sensory feedback; sex hormones; tyrosine 3 monooxygenase

DESCRIPTION (adapted from applicant's abstract): This project will use anuran amphibians as a model system to investigate the interaction of vertebrate communication behavior and hormonal control systems. Behavioral manipulations will test the hypothesis that repeated exposure to conspecific communication signals increases plasma sex steroid levels and changes the anatomical characteristics of three neurochemical systems in brain thought to be involved in hormonal regulation and reproductive control: the gonadotropin releasing hormone (GnRH) centers in the medical septal area and preoptic area expressing the mammalian LHRH form of this peptide, the tegmental GnRH center expressing the chicken II form of GnRH, and the tyrosine hydroxylase (TH) populations in the basal forebrain. Behavioral and hormonal manipulations will then test between two competing hypotheses: that any CNS changes observed are due to feedback from sex steroids released by exposure to conspecific calls vs. that CNS changes are directly due to sensory stimulation of these areas. In addition, neuroanatomical tracing experiments and immunohistochemistry will determine the connections of the medial septal LHRH areas and the tegmental chicken II GnRH area to determine which GnRH populations send efferents to the median eminence and neurohypophysis and hence may control sex steroid secretion from the gonads. Finally, sensory inputs to the medial septal area LHRH and tegmental chicken II GnRH centers will be examined to test the hypothesis that they, like the preoptic area and ventral hypothalamus centers previously examined, receive auditory input (conveying formation about communication signals) in a convergent pattern from the thalamus and isthmal tegmentum. The anatomical results will be related to the behavioral results to test the hypotheses: that both LHRH and chicken II GnRH neurons contribute to neurosecretory functions, and hence, the control of sex steroid secretion; that both forms are equally influenced by the reception of conspecific calls; and that both neurosecretory and non-neurosecretory subpopulations of each form, if such subdivisions exist, are equally influenced by the reception of conspecific calls. The project will enhance the understanding of sensory-endocrine interactions that are fundamental to a variety of natural behaviors with clinical significance, including reproduction and stress.

描述（改编自申请人的摘要）：该项目将使用 Anuran两栖动物作为模型系统，以研究 脊椎动物通信行为和激素控制系统。 行为 操纵将检验以下假设，即反复暴露于同种 沟通信号增加了血浆性类固醇水平，并改变了 大脑思想中三个神经化学系统的解剖特征 参与激素调节和生殖控制： 促性腺激素释放激素（GNRH）中心， 表达这种肽的哺乳动物LHRH形式的前区域， 对gnrh的鸡II形式的temental gnRH中心， 基底前脑中的酪氨酸羟化酶（Th）种群。 行为 然后，荷尔蒙操纵将在两个相互竞争的假设之间进行测试： 观察到的任何CNS变化都是由于释放性类固醇的反馈 通过暴露于同种呼叫，而CNS更改直接是由于 对这些区域的感觉刺激。 此外，神经解剖学追踪实验和免疫组织化学 将确定内侧间隔LHRH区域的连接和 对鸡鸡II GNRH区域以确定哪些GNRH人群发送 对中位数和神经旋转的影响，因此可以控制 性腺的性类固醇分泌。 最后，感官输入到 内侧隔膜区域LHRH和对鸡肉II GNRH中心将是 检查以检验它们，即它们像原始区域一样和 腹侧下丘脑中心先前检查过，接收听觉输入 （传达有关通信信号的形成）以收敛模式 来自丘脑和地峡的盖子。 解剖结果将是 与测试假设的行为结果有关：两个LHRH 和鸡II GNRH神经元有助于神经分泌功能，并且 因此，控制性类固醇分泌；两种形式都是同样的 受同种电话接收的影响；这两者兼而有之 每种形式的神经分泌和非神经分泌亚群，如果这样 存在分区，同样受同种接受的影响 呼叫。 该项目将增强对感觉内分泌的理解 与各种自然行为至关重要的互动 临床意义，包括繁殖和压力。