MENOPAUSE TRANSITION--BIOBEHAVIORAL MODELS OF SYMPTOMS

更年期过渡——症状的生物行为模型

• 批准号: 2714345
• 负责人: NANCY Fugate WOODS
• 金额: $ 48.81万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714345
• 关键词: androgens; behavioral /social science research tag; catecholamines; clinical research; cortisol; estradiol; estrone; female; health behavior; health care service utilization; health surveys; hormone regulation /control mechanism; human middle age (35-64); human subject; longitudinal human study; menopause; menstrual cycle; neuroendocrine system; psychobiology; psychological stressor; questionnaires; sign /symptom; social behavior; urinalysis; women's health

DESCRIPTION: (Adapted from investigator's abstract) The purpose of the proposed study is to describe the natural history of the transition to menopause, integrating the endocrine changes of the menopausal transition with features of the social context in which they occur. Perceived stress, ovarian function, physiologic stress arousal indicators (cortisol and catecholamines, adrenal androgens) will be studied in relation to symptoms and symptom management strategies. Socialization, personal factors, health behaviors and health status will be studied as they modify the relationships between perceived stress, ovarian function, stress arousal hormones, symptoms and symptom management strategies. The proposed research will involve 150 women who have participated in an ongoing longitudinal study of midlife (Seattle Midlife Women's Health Study) from 1990 to 1995. Women will participate in an annual in-home interview including measures of health status and a health history update, keep a daily bleeding calendar, provide monthly early am urine specimens for analysis for ovarian steroids (estradiol, estrone, testosterone), adrenal androgens (DHA and DHAS), cortisol and catecholamines. Women will also complete a health update annually that includes selected measures of perceived stress, personal factors, socialization, health status changes, health behaviors (Food Frequency Questionnaire, exercise questionnaire, smoking and alcohol use questions) and use of health services for symptom management. The findings of this study will contribute to an integrative understanding of how biological changes of the menopausal transition and the context in which they occur relate to symptoms that cause distress and influence women's use of health services during midlife.

描述：（改编自研究者摘要）本研究的目的