ORAL MANIFESTATIONS OF PEDIATRIC HIV INFECTION

儿童艾滋病毒感染的口腔表现

• 批准号: 2796467
• 负责人: Mark W. Kline
• 金额: $ 44.08万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2796467
• 关键词: HIV infections; dental caries; epidemiology; gingiva disorder; human subject; infant human (0-1 year); longitudinal human study; opportunistic infections; oral bacteria; oral pharyngeal disorder; pediatric AIDS; preschool child (1-5)

The proposed study will determine the prevalence and natural history of dental caries, oral mucosal and gingival lesions, and oral opportunistic diseases in infants and children with vertical HIV infection, and compare the rate of occurrence of oral manifestations in HIV-infected infants followed longitudinally with that observed in a control population of HIV-exposed but uninfected infants. The relationship between immunologic and virologic markers of HIV disease status and the prevalence and evolution of oral manifestations will be explored. Changes in the oral microbial flora (bacteria, fungi and viruses) which occur with aging and HIV disease progression will be explored and correlated with the occurrence of oral manifestations of disease. A comprehensive assessment of the etiologic nature of oral clinical pathologic lesions will be performed. Specifically, during years 1 and 2 HIV-infected infants and children will be enrolled into two study groups. Group 1 will consist of symptomatic HIV-infected subjects less than 36 months of age; group 2 will be composed of young infants with vertical HIV exposure. Infants who are confirmed HIV-infected (using sophisticated virologic techniques) will be enrolled as soon as possible after six months of age into group 2. A control group will consist of age-matched HIV-exposed infants who have tested negative for the infection. All subjects (groups 1 and 2) will undergo every six months comprehensive oral examinations and cultures, HIV disease assessments and immunologic and virologic monitoring. Intercurrent illnesses will be evaluated comprehensively. All subjects will be followed in this manner through study year 5. This study will elucidate the rate of occurrence and natural history of common and often debilitating oral manifestations of HIV infection in infants and children. In addition, it will help define the significance of oral manifestations as markers for HIV disease status. Finally, examination of changes in the oral microbial flora will help to define the pathogenesis of gingival and periodontal disease, and may have important implications with respect to HIV disease progression.

拟议的研究将确定流行和自然历史， 龋齿、口腔粘膜和牙龈病变以及口腔机会性 艾滋病毒垂直感染的婴儿和儿童的疾病，并比较 艾滋病毒感染婴儿口腔表现发生率 纵向其次是在对照人群中观察到的结果 接触艾滋病毒但未感染的婴儿。免疫学之间的关系 和艾滋病毒疾病状况和流行率的病毒学标志物， 探讨口腔症状的演变。口腔的变化 微生物植物群（细菌、真菌和病毒），它们随着衰老而出现， HIV疾病进展将被探索，并与 发生口腔疾病的表现。全面评估 口腔临床病理病变的病因学性质将是 执行。 具体而言，在第1年和第2年，感染艾滋病毒的婴儿和儿童将 被分为两个研究小组。第1组将包括症状性 年龄小于36个月的HIV感染受试者;第2组将 由垂直接触艾滋病毒的幼儿组成。的婴儿 确认感染艾滋病毒（使用先进的病毒学技术）将 在6个月大后尽快加入第2组。一 对照组将由年龄匹配的HIV暴露婴儿组成， 感染检测呈阴性所有受试者（组1和组2）将 每六个月进行一次全面的口腔检查和培养， 艾滋病毒疾病评估以及免疫学和病毒学监测。 将对并发疾病进行全面评估。所有受试者 将以这种方式进行到第5年。 这项研究将阐明的发生率和自然历史， 艾滋病毒感染的常见和经常使人衰弱的口腔表现， 婴儿和儿童。此外，它将有助于确定 口腔表现作为HIV疾病状态的标志。最后， 检查口腔微生物植物群的变化将有助于确定 牙龈和牙周病的发病机制，并可能有 对HIV疾病进展的重要影响。

项目成果

Abdominal pain and fever in an adolescent.

青少年腹痛和发烧。

• DOI: 10.1053/j.spid.2005.06.003
• 发表时间: 2005
• 期刊: Seminars in pediatric infectious diseases.
• 作者: Cazacu,AndreeaC;Cruz,AndreaT;Kaplan,SheldonL
• 通讯作者: Kaplan,SheldonL

Detection of fungal organisms in saliva from HIV-infected children: a preliminary cytologic analysis.

HIV 感染儿童唾液中真菌的检测：初步细胞学分析。

• 发表时间: 1998
• 期刊: Pediatric dentistry.
• 作者: Hicks,MJ;Carter,AB;Rossmann,SN;Demmler,GJ;Simon,CL;Cron,SG;Flaitz,CM;Shearer,WT;Kline,MW
• 通讯作者: Kline,MW