EPIDEMIOLOGY AND MANAGEMENT OF BACTERIAL KERATITIS

细菌性角膜炎的流行病学和治疗

• 批准号: 2370915
• 负责人: KIRK R WILHELMUS
• 金额: $ 12.76万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2370915
• 关键词: antibacterial agents; bacterial disease; corticosteroids; data collection methodology /evaluation; diagnosis design /evaluation; digital imaging; eye disorder chemotherapy; eye disorder diagnosis; eye fundus photography; handbook; health care professional practice; health surveys; human data; human therapy evaluation; keratitis; outcomes research; patient care management; statistics /biometry; topical drug application

This application provides a five-year plan of postgraduate education and inquiry that will permit the applicant, an ophthalmologist involved in the clinical practice of ocular infectious and inflammatory diseases and in the laboratory research of ocular microbiology, to obtain formal instruction in epidemiology and biostatistics. The planned training program for the applicant comprises coursework in the disciplines of public health leading to an M.P.H. degree at the University of Texas School of Public Health, an institution of operational excellence where there will be interaction with a scientific mentor who has experience in coordinating multicenter clinical trials in eye disease. The training period will involve a research thesis that will form the basis for developing a clinical research study on bacterial keratitis, a common ocular infection that affects approximately 1 in 8,500 Americans annually. The optimal management of bacterial keratitis has not been established. The graduate thesis of this training and research program will provide information necessary to calculate sample size and to select appropriate measurements for a clinical trial studying the role of laboratory testing, initial antibiotic selection, and adjunctive corticosteroids in bacterial keratitis. Specific aims of the research plan are to conduct a survey of ophthalmologists specializing in ocular infection to determine practice patterns of treating bacterial keratitis; to develop a data-collection instrument for recording clinical parameters and laboratory results on patients with bacterial keratitis; and to evaluate whether digital image-analysis methods of slit-lamp photographs could be used as an ancillary endpoint of bacterial keratitis outcome. This proposal is an outgrowth of the applicant's previous work and is an extension of a career development program focused on patient-oriented research.

该申请提供了研究生教育的五年计划和 询问，将允许申请人，一名参与的眼科医生 眼部感染性和炎症性疾病的临床实践和 在眼部微生物学的实验室研究中，获得正式的 流行病学和生物统计学教学。 计划的培训 申请人的课程包括以下学科的课程作业 公共卫生导致公共卫生硕士德克萨斯大学学位 公共卫生学院，一个卓越运营的机构，其中 将与有经验的科学导师互动 协调眼科疾病的多中心临床试验。 这 培训期间将涉及一篇研究论文，该论文将构成基础 为了开展细菌性角膜炎的临床研究， 常见的眼部感染，影响大约八千五百分之一的美国人 每年。 细菌性角膜炎的最佳治疗方法尚未确定。 该培训和研究计划的研究生论文将提供 计算样本量和选择适当样本所需的信息 研究实验室作用的临床试验的测量 测试、初始抗生素选择和辅助皮质类固醇 在细菌性角膜炎中。研究计划的具体目标是 对专门从事眼部感染的眼科医生进行调查 确定治疗细菌性角膜炎的实践模式；到 开发用于记录临床参数的数据收集仪器 以及细菌性角膜炎患者的实验室结果；并到 评估裂隙灯照片的数字图像分析方法是否有效 可作为细菌性角膜炎结果的辅助终点。 该提案是申请人之前工作的产物，并且是 以患者为中心的职业发展计划的延伸 研究。