EFFECTS OF BEHAVIORAL STRESS ON LIPIDS AND LIPOPROTEINS

我们正在进行的计划的目的是更好地了解生物和 应激对血脂浓度和代谢的临床重要性。 基于我们以前的研究结果，这些项目描述了 在本应用程序中的设计目的是提高我们对 行为压力、性别、敌意、应对方式与 脂类和脂蛋白浓度，并专门识别 推动这些关系的直接机制。在我们目前资助的 项目，我们已经证明了慢性和急性压力的结果 在总胆固醇、低密度脂蛋白显著增加的情况下 健康人、中年人的胆固醇(LDL-c)和甘油三酯浓度 上了年纪的人。我们的工作还确认了几个人 对应激过程中血脂变化敏感的不同变量。 在这次更新中描述的研究建立在这些发现的基础上，通过寻求 为了了解驱动这些变化的机制，并提炼我们的 理解个体差异变量如何导致不同 应激反应的脂类模式。 第一项拟议的研究将专门检验这一假设 行为应激通过改变脂质和脂蛋白浓度来改变 脂蛋白脂肪酶和肝甘油三酯脂肪酶活性。第二 拟议中的研究将专门测试行为的假设 应激改变服用安慰剂后甘油三酯的脂肪清除 静脉脂肪负荷。这两项研究都将检验这一假设 行为应激期间脂代谢的变化可通过以下方式缓解 体质(性别、年龄/绝经状况)的个体差异 和心理社会(敌意、应对、焦虑)特征。 统计分析是由假设驱动的，旨在测试 提出的模型有几条路径。 冠心病是一个主要的公共卫生问题，而 记录在案的疾病性别差异知之甚少。 心理社会特征，如敌意，也与 冠心病。在一定程度上，脂质代谢和脂质 反应性与冠状动脉病变的发生和发展有关 心脏病，这些研究将推进我们对这种方式的理解 其中行为压力、生殖荷尔蒙和心理社会 特征对脂代谢的影响以改变冠心病的风险 心脏病。

The aims of our ongoing program are to better understand the biologic and clinical importance of stress on lipid concentrations and metabolism. Building on the findings of our previous studies, the projects described in this application are designed to advance our knowledge of the relationships between behavioral stress, gender, hostility, coping, and lipid and lipoprotein concentrations, and to specifically identify the direct mechanisms driving these relationships. In our currently funded projects, we have demonstrated that both chronic and acute stress result in significant increases in total cholesterol, low density lipoprotein- cholesterol (LDL-c) and triglyceride concentrations in healthy, middle- aged individuals. Our work has also identified several individual difference variables that are sensitive to lipid changes during stress. The studies described in this renewal build on these findings by seeking to understand the mechanisms driving these alterations, and to refine our understanding of how individual difference variables result in distinct lipid patterns of response to stress. The first proposed study will specifically test the hypothesis that behavioral stress alters lipid and lipoprotein concentrations by altering lipoprotein lipase and hepatic triglyceride lipase activity. The second proposed study will specifically test the hypothesis that behavioral stress alters triglyceride fat clearance after administration of an intravenous fat load. Both studies will test the hypothesis that alterations in lipid metabolism during behavioral stress are moderated by individual differences in constitutional (gender, age/menopausal status) and psychosocial (hostility, coping, anxiety) characteristics. Statistical analyses are hypothesis-driven, and are designed to test several pathways of the proposed model. Coronary heart disease is a major public health concern and the well- documented gender differences in disease are poorly understood. Psychosocial characteristics such as hostility are also associated with coronary heart disease. To the extent that lipid metabolism and lipid reactivity are relevant to the initiation and progression of coronary heart disease, these studies will advance our understanding of the manner in which behavioral stress, reproductive hormones, and psychosocial characteristics impact on lipid metabolism to alter risk for coronary heart disease.