EFFECTS OF BEHAVIORAL STRESS ON LIPIDS AND LIPOPROTEINS

我们正在进行的项目的目的是更好地了解生物和 应激对脂质浓度和代谢的临床重要性。 根据我们以前的研究结果，所描述的项目 在这个应用程序的目的是提高我们的知识 行为压力、性别、敌意、应对和 脂质和脂蛋白浓度，并具体确定 推动这些关系的直接机制。 在我们目前资助的 项目，我们已经证明，无论是慢性和急性压力的结果， 总胆固醇、低密度脂蛋白 胆固醇（LDL-c）和甘油三酯浓度在健康，中等， 老年人。 我们的工作还发现了几个 差异变量是敏感的脂质变化在压力。 本更新中描述的研究建立在这些发现的基础上， 了解驱动这些变化的机制，并完善我们的 理解个体差异变量如何导致不同的 对压力反应的脂质模式。 第一项拟议的研究将具体检验以下假设： 行为应激改变脂质和脂蛋白浓度， 脂蛋白脂肪酶和肝甘油三酯脂肪酶活性。 第二 拟议的研究将专门测试的假设，行为 应激改变了三酸甘油酯脂肪清除率， 静脉脂肪负荷。 这两项研究都将检验以下假设： 行为应激期间脂质代谢的改变受到以下因素的调节： 体质的个体差异（性别、年龄/绝经状态） 和社会心理（敌意、应对、焦虑）特征。 统计分析是假设驱动的，旨在检验 提出的几种模式。 冠心病是一个主要的公共卫生问题， 人们对疾病中有记录的性别差异知之甚少。 社会心理特征，如敌意，也与 冠心病 在某种程度上，脂质代谢和脂质 反应性与冠状动脉粥样硬化的发生和进展有关 心脏病，这些研究将促进我们的方式的理解， 其中行为压力、生殖激素和心理社会 特征对脂质代谢的影响改变冠状动脉粥样硬化的风险 心脏病

The aims of our ongoing program are to better understand the biologic and clinical importance of stress on lipid concentrations and metabolism. Building on the findings of our previous studies, the projects described in this application are designed to advance our knowledge of the relationships between behavioral stress, gender, hostility, coping, and lipid and lipoprotein concentrations, and to specifically identify the direct mechanisms driving these relationships. In our currently funded projects, we have demonstrated that both chronic and acute stress result in significant increases in total cholesterol, low density lipoprotein- cholesterol (LDL-c) and triglyceride concentrations in healthy, middle- aged individuals. Our work has also identified several individual difference variables that are sensitive to lipid changes during stress. The studies described in this renewal build on these findings by seeking to understand the mechanisms driving these alterations, and to refine our understanding of how individual difference variables result in distinct lipid patterns of response to stress. The first proposed study will specifically test the hypothesis that behavioral stress alters lipid and lipoprotein concentrations by altering lipoprotein lipase and hepatic triglyceride lipase activity. The second proposed study will specifically test the hypothesis that behavioral stress alters triglyceride fat clearance after administration of an intravenous fat load. Both studies will test the hypothesis that alterations in lipid metabolism during behavioral stress are moderated by individual differences in constitutional (gender, age/menopausal status) and psychosocial (hostility, coping, anxiety) characteristics. Statistical analyses are hypothesis-driven, and are designed to test several pathways of the proposed model. Coronary heart disease is a major public health concern and the well- documented gender differences in disease are poorly understood. Psychosocial characteristics such as hostility are also associated with coronary heart disease. To the extent that lipid metabolism and lipid reactivity are relevant to the initiation and progression of coronary heart disease, these studies will advance our understanding of the manner in which behavioral stress, reproductive hormones, and psychosocial characteristics impact on lipid metabolism to alter risk for coronary heart disease.