GENETIC EPIDEMIOLOGY OF GASTRIC CANCER

胃癌的遗传流行病学

• 批准号: 2751372
• 负责人: CHARLES P THEUER
• 金额: $ 7.51万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2751372
• 关键词: Helicobacter; antibacterial antibody; clinical research; disease /disorder etiology; family genetics; genetic susceptibility; human subject; neoplasm /cancer epidemiology; neoplasm /cancer genetics; stomach neoplasms

Description: (Applicant's Description) Gastric cancer is the eleventh leading cause of cancer-related deaths in the United States and remains one of the most serious worldwide health burdens. Upper endoscopy is effective in the diagnosis of gastric cancer and surgery for localized disease is usually curative. The majority of gastric cancer patients, however, are diagnosed at a late stage of the disease and die soon after diagnosis. Studies have not identified subgroups of patients in whom screening to detect early gastric cancer may be effective. Further gastric cancer studies are needed to determine its environmental and genetic risk factors particularly using population-based patients and their families so that cancer prevention and control strategies can be developed. We propose to integrate techniques in genetic epidemiology and molecular biology to develop a means of identifying and characterizing inherited gastric cancer predisposing syndromes. The model will consider genetic factors that may be associated with tumor aggressiveness, environmental exposures and interactions among these factors. We will assemble a population-based series of approximately 350 gastric cancer cases and controls to assess the etiologic component associated with familial and potentially hereditary predisposition and to compare clinical, pathologic and prognostic features in sporadic, familial, and potentially hereditary gastric cancer. Methods already developed by the Epidemiology Division of UCI will be used to collect family history, epidemiologic risk factors, biologic samples (serum, lymphocytes, and paraffin-embedded tumor and normal tissue). We will test all gastric cancer cases for the replication error phenotype at microsatellites at seven loci. We will also test patient serum for IgG to Helicobacter pylori. Gene testing will be done on potential hereditary cases, focusing on the p53 and mismatch repair gene loci. This case-control study of possible genetic mutations will allow identification of populations at high risk for this cancer where opportunities for prevention and early detection of gastric cancer can be realized.

职位描述：(应聘者描述)胃癌排在第11位 美国癌症相关死亡的主要原因之一 全球最严重的健康负担之一。高位内窥镜检查有效 在胃癌的诊断和局部疾病的外科手术中 通常是治愈的。然而，大多数胃癌患者是 在疾病晚期被诊断出来，并在被诊断后不久死亡。 研究尚未确定在哪些患者中进行筛查以 发现早期胃癌可能是有效的。进一步的胃癌 需要研究以确定其环境和遗传风险因素。 特别是使用以人口为基础的患者及其家人，以便 可以制定癌症预防和控制策略。我们建议 结合遗传流行病学和分子生物学的技术来 开发一种识别和表征遗传性胃癌的方法 易感综合征。该模型将考虑可能存在的遗传因素 与肿瘤侵袭性、环境暴露和 这些因素之间的相互作用。我们将组建一个以人口为基础的 一系列大约350例胃癌病例和对照的评估 与家族性和潜在遗传性相关的病因学成分 并比较临床、病理和预后特征 在散发性、家族性和潜在遗传性胃癌中。方法 已经由UCI流行病学部开发的将被用于 收集家族史、流行病学危险因素、生物样本(血清、 淋巴细胞、石蜡包埋肿瘤和正常组织)。我们将测试 所有胃癌病例的复制错误表型均为 七个基因座的微卫星。我们还将检测患者血清中的免疫球蛋白以 幽门螺杆菌。将对潜在的遗传病患者进行基因检测 2例，主要集中在P53和错配修复基因座。这一病例对照 对可能的基因突变的研究将使人们能够识别 这种癌症的风险很高，预防的机会和早期 可以实现对胃癌的检测。