HOST CELL CYCLE REGULATION IN TRICHINELLOSIS

旋毛虫病的宿主细胞周期调控

• 批准号: 2671355
• 负责人: DOUGLAS P JASMER
• 金额: $ 6.8万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2671355
• 关键词: Trichinella; cell cycle; cell line; cellular pathology; complementary DNA; gene expression; host organism interaction; intracellular parasitism; laboratory mouse; laboratory rabbit; laboratory rat; molecular pathology; muscle cells; polymerase chain reaction; southern blotting; striated muscles; tissue /cell culture; trichinosis

This research focus is in molecular and cellular aspects of host/parasite interactions. Immediate goals are to establish a sustainable, high quality research program which makes meaningful progress toward control of infectious diseases. Long-term goals are to make significant scientific contributions to the area of host/parasite interactions, to train new independent investigators, and to advance this research area through multidisciplinary collaborations, preparation of topical reviews, and service on peer review and journal editorial boards. Infection by Trichinella spirallis induces skeletal muscle cells to enter into S phase, which then become suspended in G2/M of the cell cycle throughout the course of infection, which can last for years. This novel effect on skeletal muscle cells is associated with the apparent dedifferentiation of muscle cells. Research is aimed at identifying parasite factors that induce these host changes. The research has broad application to infectious diseases and basic cell biology.

本研究的重点是在分子和细胞 宿主/寄生虫的相互作用。近期目标是建立一个 可持续、高质量的研究项目，取得有意义的进展 控制传染病。长期目标是使 对宿主/寄生虫领域的重大科学贡献 互动，培训新的独立调查人员，并推动这一点， 研究领域通过多学科合作，编制 专题评论，并为同行评议和期刊编辑委员会提供服务。 旋毛虫感染诱导骨骼肌细胞进入 进入S期，然后悬浮在细胞周期的G2/M期 在整个感染过程中，这可能会持续数年。这本小说 对骨骼肌细胞的作用与 肌细胞的去分化。研究旨在确定 寄生虫的因素引起这些主机的变化。该研究具有广泛的 应用于传染病和基础细胞生物学。