Motion-adaptive PET technology for brain imaging of freely moving mice

用于自由移动小鼠脑部成像的运动自适应 PET 技术

• 批准号: DP190102318
• 负责人: Prof Steven Meikle
• 金额: $ 34.02万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102318
• 关键词: Motion; adaptive; PET; technology; brain

This project aims to develop new brain imaging technology that adapts to and corrects for the motion of a responsive, freely moving mouse. Current technology requires the subject to be unconscious, precluding the use of imaging to study signalling pathways activated by external stimuli during cognitive and behavioural tasks. By harnessing new radiation detector, motion tracking and computational technologies, the project expects to bridge this technology gap and provide significant technical and conceptual advances in the field. This will provide important benefits, such as equipping neuroscientists with new tools to answer fundamental questions about how the mammalian brain regulates behavioural adaptation to a changing environment.

该项目旨在开发新的大脑成像技术，以适应和纠正反应灵敏、自由移动的鼠标的运动。目前的技术要求受试者是无意识的，排除了使用成像来研究在认知和行为任务期间由外部刺激激活的信号通路。通过利用新的辐射探测器、运动跟踪和计算技术，该项目有望弥合这一技术差距，并在该领域提供重大的技术和概念进步。这将提供重要的好处，例如为神经科学家提供新的工具来回答有关哺乳动物大脑如何调节行为适应变化环境的基本问题。