Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals

同时测量完全清醒的实验动物的大脑功能和行为

• 批准号: DP0988166
• 负责人: Prof Steven Meikle
• 金额: $ 22.84万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-05-25 至 2012-05-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988166
• 关键词: Simultaneous; measurement; brain; function; behaviour

MicroPET is an advanced imaging technology that measures important biochemical processes, such as enzyme activity rates and receptor binding, in the living rodent brain. However, the requirement for the animal to be anaesthetised precludes the study of behavioural changes in response to sensory or drug stimulus during the imaging study. In this research, we will develop novel motion tracking and computational algorithms that enable microPET to non-invasively image the brains of conscious, freely moving animals while simultaneously observing their behaviour. These new technologies will, for the first time, allow neuroscientists to study the genetic, behavioural and neurochemical correlates of brain disease.

MicroPET是一种先进的成像技术，可以测量活体啮齿动物大脑中的重要生化过程，如酶活性率和受体结合。然而，对动物进行麻醉的要求排除了在成像研究期间对感觉或药物刺激反应的行为变化的研究。在这项研究中，我们将开发新的运动跟踪和计算算法，使microPET能够非侵入性地对有意识的、自由移动的动物的大脑进行成像，同时观察它们的行为。这些新技术将首次允许神经科学家研究大脑疾病的遗传、行为和神经化学相关性。