NEUROPSYCHOLOGY

神经心理学

• 批准号: 5204410
• 负责人: MARILYN S ALBERT
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5204410
• 关键词: Alzheimer's disease; age difference; aging; brain disorder diagnosis; cognition; cognition disorders; human subject; longitudinal human study; neuroanatomy; neurophysiology; neuropsychological tests; neuropsychology

Project 1 will focus on two primary goals. The first concerns the cognitive changes that occur with age and their relationship to neuroanatomic and neurophysiologic changes in the brain. Toward this end data from 200 optimally healthy subjects (approximately 100 males and 100 females) will be examined. Most of these data will have been gathered in previous funding periods, however, some data will be gathered in the next funding period in order to permit state-of-the art MRI analyses. A variety of statistical techniques will be employed to evaluate age-related change. The second primary goal of Project 1 concerns dementia of the Alzheimer type (AD). One hundred and twenty five questionable cases of AD (CDR=0.5) and forty normal controls (CDR=0) will be followed for a minimum of 3 years. It is anticipated that approximately 2/3 of the questionable cases (n=80) will be categorized as AD by the end of the follow-up period. This will permit an examination o the cognitive differences between questionable cases who are diagnosed as AD on follow-up and questionable cases who are not. It will also permit the evaluation of the relationship between cognitive test scores and quantified measures of brain structure and function (i.e., qEEG, MRI, SPECT) in these very mildly impaired patients.

项目1将重点关注两个主要目标。第一个问题是关于 随年龄增长的认知变化及其与年龄的关系 大脑的神经解剖学和神经生理学变化。朝着这个目标前进 来自200名最佳健康受试者的数据(大约100名男性和100名 女性)将接受检查。这些数据中的大部分将收集到 然而，前几个资助期的一些数据将在下一个资助期收集 资助期，以便进行最先进的核磁共振分析。品种繁多 将使用统计技术来评估与年龄相关的变化。 项目1的第二个主要目标是老年痴呆症 类型(AD)。125例AD疑似病例(CDR=0.5%) 40名正常对照(CDR=0)将被跟踪至少3次 好几年了。预计大约三分之二的可疑案件 (n=80)将在随访期结束时被归类为AD。这 将允许对可疑的认知差异进行检查 被诊断为阿尔茨海默病的病例和有疑问的病例 不。它还将允许评估两国之间的关系 认知测试分数和脑结构和脑功能的量化测量 这些非常轻微受损的患者的功能(即qEEG、MRI、SPECT)。