ALZHEIMERS DISEASE IMAGING: IMAGE DATA TO IDENTIFY EARLY MARKERS OF AD

阿尔茨海默病成像：识别 AD 早期标志物的图像数据

• 批准号: 6123558
• 负责人: MARILYN S ALBERT
• 金额: $ 1.96万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123558
• 关键词: aging; bioengineering /biomedical engineering; biomedical resource; nervous system

Program Project on aging and Alzheimer's disease has been continuously funded since 1980, with Dr. Marilyn Albert as the PI. It was originally designed to study normal aging and Alzheimer's disease (AD), using neuropsychological and neuroimaging techniques. With the inception of the last funding period, the emphasis on Alzheimer's disease was expanded to include early detection in "questionable" patients; this now represents the primary focus of the research efforts. This Program Project was recently reviewed and we expect, on the basis of discussions with the funding agency, that it will be renewed. The specific aims of the Program Project are: (1) to recruit a large sample of subjects who meet criteria for "questionable" AD and a group of controls, (2) to evaluate the subjects at baseline with neuropsychological testing, neuroimaging procedures (i.e., Single Photon Emission Tomography [SPECT], Magnetic Resonance Imaging [MRI], and functional MRI [fMRI], and genetic testing (e.g., APOE-4 genotype), (3) to follow participants annually to determine which subjects develop AD over time, and (4) to examine the measures that predict progression of cognitive decline and the development of AD, both within and across the domains evaluated. Our research program is based on the Central Hypothesis that the development of AD follows a lengthy trajectory before full-blown symptoms are evident and that, in late-onset cases (patients who develop AD over the age of 65), disease is the result of multiple converging factors. Thus, it is likely that even very mildly impaired AD patients have substantial pathology in selected brain regions and therefore, by merging measurement of cognitive abilities and brain function related to these regions with an assessment of some of the factors that increase risk for disease, patients in the earliest stages of AD can be identified with considerable accuracy. This Central Hypothesis leads to several specific hypotheses with respect to the present Program Project:

关于老龄化和阿尔茨海默病的计划项目已经 自1980年以来一直得到资助，Marilyn Albert博士担任PI。 它 最初是为了研究正常衰老和阿尔茨海默病而设计的 (AD)采用神经心理学和神经影像学技术。 随着上一个供资期的开始， 老年痴呆症被扩大到包括早期发现， “可疑”的病人;这现在是主要的焦点， 研究工作。 该计划项目最近进行了审查，我们 根据与供资机构的讨论，预计 将被续订。 该计划项目的具体目标是：（1） 招募大量符合以下标准的受试者样本 “可疑”AD和一组对照，（2）评估 基线时接受神经心理学测试、神经影像学检查的受试者 程序（即，单光子发射断层扫描[SPECT]，磁性 共振成像[MRI]和功能性MRI [fMRI]，以及遗传 测试（例如，APOE-4基因型），（3）每年随访参与者 以确定哪些受试者随着时间的推移发展AD，以及（4）检查 预测认知能力下降进展的指标， AD的发展，无论是在内部和跨领域的评价。 我们的研究计划是基于中心假设， AD的发展在全面成熟之前遵循一个漫长的轨迹， 症状是明显的，在晚发病例中（ 发展AD超过65岁），疾病是多种疾病的结果， 趋同因素 因此，即使是非常轻微的受损， AD患者在选定的脑区域中具有实质性病理， 因此，通过合并认知能力和大脑的测量， 与这些区域有关的职能， 增加疾病风险的因素，最早的患者 可以相当准确地识别AD的阶段。 这 中心假设导致了几个具体的假设， 目前的项目计划：