HLA CLASS II ANTIGEN PRESENTATION DURING VIRAL INFECTION

病毒感染期间 HLA II 类抗原呈递

• 批准号: 2671417
• 负责人: NEAL R NYGARD
• 金额: $ 8.75万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2671417
• 关键词: MHC class II antigen; T lymphocyte; antigen presentation; antigen presenting cell; human tissue; influenza; influenzavirus A; peptide chemical synthesis; recombinant proteins; synthetic peptide; tissue /cell culture; virus antigen; virus protein

DESCRIPTION: The principal investigator proposes to investigate the structure and intracellular trafficking of HLA class II binding peptides originating from viral and endogenous proteins during influenza infection. The objectives of the study are to: (1) characterize naturally processed influenza peptides bound to HLA class II molecules, (2) examine the trafficking and processing of cytosolic influenza proteins in the class II presentation pathway, and (3) assess the effect of influenza infection on the binding of self peptides to class II molecules.

产品说明： 主要研究者建议研究结构， HLA-II类结合肽的细胞内运输 病毒和内源性蛋白质。 的目标 本研究目的是：（1）表征天然加工的流感肽 结合HLA II类分子，（2）检查运输和加工 II类呈递途径中的胞质流感蛋白，以及 (3)评估流感感染对自身肽结合的影响 到II类分子。