ECOLOGICALLY GUIDED BIOPROSPECTING IN PANAMA

巴拿马的生态引导生物勘探

• 批准号: 2722193
• 负责人: PHYLLIS D COLEY
• 金额: $ 49.04万
• 依托单位: SMITHSONIAN INSTITUTION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2722193
• 关键词: Central America; Coleoptera; Fungi; cooperative study; drug screening /evaluation; medicinal plants; plant extracts

DESCRIPTION: (Applicant's Description) Our objectives are to build a sustainable bioprospecting program in Panama, to e n hance conservation, and to discover new products for medicine and agriculture. Panama has more forest cover than any other Central American country, and is considered a threatened diversity hotspot. Its unique p o sition as a biological corridor joining the northern and southern hemispheres has implications for both regional and international conservation strategies. To promote conservation and sustainable bioprospecting in Panama, we are stressing technology transfer and effective drug discovery. First, we will use ecological research to target collections towards species and tissues that have a high biological activity. We will also extract fresh samples, minimizing the loss of active compounds. Second, we are placing a large emphasis on training and technology transfer to Panama. We are establishing bioassay with Human Immunodeficiency Virus (HIV) and cancer at the University of Panama and with tropical diseases at Gorgas Memorial Institute in Panama City. Active compounds will purified at the University of Panama. In addition, protein extracts will be tested for activity against whitefly, a crop pest that could become one of the major pests worldwide. Both organic and protein extracts will be sent to Monsanto, our industrial collaborator. Monsanto has committed to providing strong technical support for the pharmaceutical and agricultural investigations in Panama, especially with the identification of active compounds, thus providing a substantial component of capacity building. This emphasis on training and technology transfer creates immediate benefits to Panama and helps establish the scientific infrastructure necessary to continue bioprospecting after the termination of the grant. In addition we will assist the Kuna and Naso Indians of Panama to make a permanent record of their ethnobotanical knowledge and to increase their involvement in conservation and land management planning.

描述：（申请人的描述） 我们的目标是在巴拿马建立可持续的生物镜头计划， 为了保存范围，并发现用于医学的新产品 农业。 巴拿马的森林封面比其他任何中美洲都要多 国家，被认为是受威胁的多样性热点。 它独特的p o 作为加入北部和南部的生物走廊的地点 半球对区域和国际都有影响 保护策略。 促进保护和可持续性 在巴拿马，我们强调技术转移和有效 药物发现。 首先，我们将使用生态研究来针对 对具有较高生物学的物种和组织的收集 活动。 我们还将提取新鲜样品，最大程度地减少活性的损失 化合物。 其次，我们非常重视培训和 技术转移到巴拿马。 我们正在与人类建立生物测定 巴拿马大学的免疫缺陷病毒（HIV）和癌症 巴拿马城戈尔加斯纪念研究所的热带疾病。 积极的 化合物将在巴拿马大学纯化。 另外，蛋白质 提取物将测试针对粉虱的活动，这是一种农作物害虫 可以成为全球主要的害虫之一。 有机和蛋白质 提取物将被发送给我们的工业合作者孟山都。 孟山都 致力于为药品提供强大的技术支持 以及巴拿马的农业调查，尤其是 识别活性化合物，从而提供了实质性的成分 能力建设。 强调培训和技术转移 为巴拿马带来直接的好处，并帮助建立科学 终止后继续生物培训所需的基础设施 赠款。 此外，我们将协助巴拿马的Kuna和Naso印第安人 永久记录其民族植物学知识并增加 他们参与保护和土地管理计划。