ESCAPE BEHAVIOR INTEGRATION AND PLASTICITY

这项研究的目的是促进我们对 负责学习和反应选择的神经元机制 复杂的综合行为系统 这些相关问题将在一个相对简单的系统中进行研究， 小龙虾的侧向巨大逃逸反应回路， 受到各种形式的控制和调节。 行为和电生理学的研究建议在（1）神经 下行紧张性抑制系统的组织和药理学， 调节外侧巨逸兴奋性并参与习惯化 也许是逃避的联想学习， 竞争活动中的逃避，（2）补药的可能作用 抑制重新编程较低级别的电路， （3）递质的可能作用 自身受体诱导习惯化，（4）神经化学 敏感化学习的媒介。计算研究建议在 选择压力导致了特定模式的存在， 识别神经元和响应专用触发神经元 考虑到这些选择的可能的一般性 压力

The purpose of this research is to contribute to our understanding of the neuronal machinery responsible for learning and response selection in complex, integrated behavioral repertoires. These related problems are to be studied in a relatively simple system, the lateral giant escape reaction circuit of the crayfish, which is subject to a variety of forms of control and modulation. Behavioral and electrophysiological research is proposed on (1) the neural organization and pharmacology of a descending tonic inhibitory system that modulates lateral giant escape excitability and is involved in habituation and perhaps associative learning of escape as well as suppression of escape during competing activities, (2) the possible role of tonic inhibition in reprogramming lower level circuitry so that the intrinsic excitability of escape is readjusted, (3) the possible role of transmitter auto-receptors in inducing habituation, and (4) the neurochemical mediators of sensitization learning. Computational research is proposed on the selection pressures that resulted in the existence of pattern-specific recognition neurons and response-dedicated trigger neurons in this system with a consideration of the possible generality of these selection pressures.