ESCAPE BEHAVIOR INTEGRATION AND PLASTICITY

这项研究的目的是为了帮助我们理解 负责学习和反应选择的神经元机制 复杂、完整的行为模式。 这些相关问题将在一个相对简单的系统中进行研究， 小龙虾的侧向巨型逃逸反应回路，即 受制于各种形式的控制和调制。 行为学和电生理学的研究主要集中在(1)神经 一种下行紧张性抑制系统的组织和药理学 调节侧方巨大逃逸兴奋性，并参与习惯化 也许是对逃避和抑制的联想学习 在竞技活动中逃生，(2)补药的可能作用 在对低电平电路重新编程时的抑制，从而使本征 逃逸兴奋性的重新调整；(3)递质的可能作用 诱导习惯化的自身受体，以及(4)神经化学 敏感化学习的中介。提出了关于计算研究的建议 导致特定模式存在的选择压力 该系统中的识别神经元和反应专属触发神经元 考虑到这些选择可能具有的一般性 压力。

The purpose of this research is to contribute to our understanding of the neuronal machinery responsible for learning and response selection in complex, integrated behavioral repertoires. These related problems are to be studied in a relatively simple system, the lateral giant escape reaction circuit of the crayfish, which is subject to a variety of forms of control and modulation. Behavioral and electrophysiological research is proposed on (1) the neural organization and pharmacology of a descending tonic inhibitory system that modulates lateral giant escape excitability and is involved in habituation and perhaps associative learning of escape as well as suppression of escape during competing activities, (2) the possible role of tonic inhibition in reprogramming lower level circuitry so that the intrinsic excitability of escape is readjusted, (3) the possible role of transmitter auto-receptors in inducing habituation, and (4) the neurochemical mediators of sensitization learning. Computational research is proposed on the selection pressures that resulted in the existence of pattern-specific recognition neurons and response-dedicated trigger neurons in this system with a consideration of the possible generality of these selection pressures.