课题基金 / 基金详情

TARGET SPECIFIC EMULSION FOR SYSTEMIC GENE DELIVERY

TARGET SPECIFIC EMULSION FOR SYSTEMIC GENE DELIVERY
用于全身基因传递的目标特异性乳液
批准号：
2654251
负责人：
DEXI LIU
金额：
$10.22万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-01 至 2002-01-31
来源：
https://reporter.nih.gov/project-details/2654251
关键词：
biomaterial development /preparation biomaterial evaluation disease /disorder model drug delivery systems electron microscopy emulsions gene expression gene targeting laboratory mouse lipid biosynthesis lipid structure liposomes lung neoplasms monoclonal antibody neoplastic cell nucleic acid structure tissue /cell culture transfection transfection /expression vector

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中文摘要
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英文摘要
Gene therapy is a conceptually new approach for the treatment of human disease. It requires a carrier to deliver to the target cells a piece of DNA containing genes that are effective in manipulating cellular function. In this project, we propose to develop an emulsion based carrier system for gene delivery. The main objective of this proposal is (1) to optimize delivery efficiency of emulsion-based carrier system; (2) to study the mechanisms involved In emulsion-mediated gene delivery; and (3) to develop target-specific, emulsion-based gene carrier system.
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