TARGET SPECIFIC EMULSION FOR SYSTEMIC GENE DELIVERY

用于全身基因传递的目标特异性乳液

• 批准号: 2871925
• 负责人: DEXI LIU
• 金额: $ 10.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2871925
• 关键词: biomaterial development /preparation; biomaterial evaluation; disease /disorder model; drug delivery systems; electron microscopy; emulsions; gene expression; gene targeting; laboratory mouse; lipid biosynthesis; lipid structure; liposomes; lung neoplasms; monoclonal antibody; neoplastic cell; nucleic acid structure; tissue /cell culture; transfection; transfection /expression vector

Gene therapy is a conceptually new approach for the treatment of human disease. It requires a carrier to deliver to the target cells a piece of DNA containing genes that are effective in manipulating cellular function. In this project, we propose to develop an emulsion based carrier system for gene delivery. The main objective of this proposal is (1) to optimize delivery efficiency of emulsion-based carrier system; (2) to study the mechanisms involved In emulsion-mediated gene delivery; and (3) to develop target-specific, emulsion-based gene carrier system.

基因治疗是治疗人类疾病的一种新的概念方法。 疾病。它需要承运人向目标细胞递送一块 含有能有效操纵细胞的基因的DNA 功能。在这个项目中，我们建议开发一种基于 用于基因传递的载体系统。这项提议的主要目标是 (1)优化乳剂载体系统的输送效率；(2) 研究乳剂介导的基因传递的机制；以及 (3)研制靶向性、乳剂型基因载体系统。