课题基金 / 基金详情

TARGET SPECIFIC EMULSION FOR SYSTEMIC GENE DELIVERY

TARGET SPECIFIC EMULSION FOR SYSTEMIC GENE DELIVERY
用于全身基因传递的目标特异性乳液
批准号：
2871925
负责人：
DEXI LIU
金额：
$10.26万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-01 至 2002-01-31
来源：
https://reporter.nih.gov/project-details/2871925
关键词：
biomaterial development /preparation biomaterial evaluation disease /disorder model drug delivery systems electron microscopy emulsions gene expression gene targeting laboratory mouse lipid biosynthesis lipid structure liposomes lung neoplasms monoclonal antibody neoplastic cell nucleic acid structure tissue /cell culture transfection transfection /expression vector

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相关文献

中文摘要
翻译
基因治疗是治疗人类疾病的一种新的概念方法。 疾病。它需要承运人向目标细胞递送一块 含有能有效操纵细胞的基因的DNA 功能。在这个项目中，我们建议开发一种基于 用于基因传递的载体系统。这项提议的主要目标是 (1)优化乳剂载体系统的输送效率；(2) 研究乳剂介导的基因传递的机制；以及 (3)研制靶向性、乳剂型基因载体系统。
英文摘要
Gene therapy is a conceptually new approach for the treatment of human disease. It requires a carrier to deliver to the target cells a piece of DNA containing genes that are effective in manipulating cellular function. In this project, we propose to develop an emulsion based carrier system for gene delivery. The main objective of this proposal is (1) to optimize delivery efficiency of emulsion-based carrier system; (2) to study the mechanisms involved In emulsion-mediated gene delivery; and (3) to develop target-specific, emulsion-based gene carrier system.
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Computer-Assisted Hydrodynamic Gene Delivery for Hemophilia Gene Therapy
Computer-Assisted Hydrodynamic Gene Delivery for Hemophilia Gene Therapy
  • 批准号：
    8434877
  • 项目类别：
  • 资助金额：
    $30.93万
  • 财政年份：
    2009
  • 负责人：
    DEXI LIU
  • 依托单位：
    UNIVERSITY OF GEORGIA
Computer-Assisted Hydrodynamic Gene Delivery for Hemophilia Gene Therapy
  • 批准号：
    8197392
  • 项目类别：
  • 资助金额：
    $51.54万
  • 财政年份：
    2009
  • 负责人：
    DEXI LIU
  • 依托单位：
    UNIVERSITY OF GEORGIA
Computer-Assisted Hydrodynamic Gene Delivery for Hemophilia Gene Therapy