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RHEUMATOID FACTOR--GENETICS, PATHOGENESUS AND MODULATION

RHEUMATOID FACTOR--GENETICS, PATHOGENESUS AND MODULATION
类风湿因子——遗传学、发病机制和调节
批准号：
6279224
负责人：
DENNIS A CARSON
金额：
$1.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6279224
关键词：
Escherichia coli T lymphocyte antibody specificity bacterial proteins blood chemistry clinical research gene expression genetic mapping human subject immunopathology pathologic process rheumatoid arthritis synovial fluid

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英文摘要
Determine the role of molecular mimicry in the immunopathogenesis of rheumatoid arthritis by comparing the magnitude and specificity of antibodies to the E-coli DNAJ and proteins in the synovial fluids and bloods of patients with early RA and normal subjects, assess the magnitude and specificity of the T cell immune response to E. coli DNAJ proteins and determine what T cell receptor variable region genes are used for anti- DNAJ immune responses in RA synovial fluid and blood.
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