RHEUMATOID FACTOR--GENETICS, PATHOGENESUS AND MODULATION

类风湿因子——遗传学、发病机制和调节

• 批准号: 6279224
• 负责人: DENNIS A CARSON
• 金额: $ 1.43万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279224
• 关键词: Escherichia coli; T lymphocyte; antibody specificity; bacterial proteins; blood chemistry; clinical research; gene expression; genetic mapping; human subject; immunopathology; pathologic process; rheumatoid arthritis; synovial fluid

Determine the role of molecular mimicry in the immunopathogenesis of rheumatoid arthritis by comparing the magnitude and specificity of antibodies to the E-coli DNAJ and proteins in the synovial fluids and bloods of patients with early RA and normal subjects, assess the magnitude and specificity of the T cell immune response to E. coli DNAJ proteins and determine what T cell receptor variable region genes are used for anti- DNAJ immune responses in RA synovial fluid and blood.

确定分子模拟在免疫发病机制中的作用 类风湿性关节炎的程度和特异性 滑液中的大肠杆菌DNAJ抗体和蛋白质， 早期RA患者和正常人的血液，评估 和T细胞免疫应答的特异性。coli DNAJ蛋白， 确定哪些T细胞受体可变区基因用于抗- RA滑液和血液中的DNAJ免疫应答。