TRAINING PROGRAM IN BIOORGANIC CHEMISTRY

生物有机化学培训计划

• 批准号: 2654849
• 负责人: ROBERT H ABELES
• 金额: $ 14.04万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2654849
• 关键词: TRAINING; PROGRAM; BIOORGANIC; CHEMISTRY

The Bioorganic Training Grant, which is now submitted for renewal, has played an important role in science education at Brandeis. It gave rise to a group of graduate students with novel interests and novel capabilities. It was the goal of this program to train investigators who can work at the interphase of biology, biochemistry, and chemistry. We have been successful. It is apparent, from listening to rotation reports, that chemists can use, and understand techniques of molecular biology, and biologists can synthesize compounds. This combination of skills is in demand by the pharmaceutical industry, and should facilitate future health related research. The program started with zero students and now contains 18 students. Trainees are appointed on the basis of their strong academic record and evidence of their research ability. In the first year of graduate training they begin to participate in a program, which consists of a core curriculum of seven courses. Students take these courses in their first two years of the program. The core curriculum consists of two semesters of Advanced Biochemistry (Biochemistry 101A & 101B), one semester of Advanced Organic Synthesis (Chemistry 134), one semester of Molecular Biology (Biology 105), one semester of Mechanistic Organic Chemistry (selected from Chemistry 131, 133, or Biochemistry 202), one semester of an advance course in spectroscopy or crystallographic structure determination (selected from Chemistry 132, 229, or 235), and finally one elective, selected from offerings in the Chemistry, Biochemistry, Biology or Neuroscience programs. First year students also undertake six, six-week rotations in different laboratories in the program. The students must complete half of their rotations on problems which focus on chemical synthesis. This can be accomplished by rotating in laboratories of faculty from the Chemistry Department or, where appropriate, in laboratories from the Biochemistry Department. A written report and oral presentation of the results are given at the end of each rotation. The purpose of the rotations is two-fold. First, is to give students exposure to many different faculty so as to facilitate their choice of mentor and to give them a broad experience with different approaches to scientific problems. Second, the rotations are a means of ensuring hands-on synthesis experience for all of our students early in the scientific careers. In addition students participate in seminars and journal clubs throughout their stay.

现已提交续签的生物有机培训补助金已有 在Brandeis的科学教育中发挥了重要作用。它产生了 给一群具有新颖兴趣和新颖的研究生 功能。该计划的目标是培训调查人员 可以在生物学，生物化学和化学的相间工作。 我们 已经成功了。很明显，从聆听旋转报告， 化学家可以使用并了解分子生物学的技术， 生物学家可以合成化合物。这种技能的结合是 制药行业的需求，应该促进未来 健康相关研究。该计划从零学生开始，现在 包含18名学生。学员是根据他们的强者而任命的 学术记录和研究能力的证据。 在第一个 他们的研究生培训年开始参加一项计划，该计划 由七个课程的核心课程组成。学生接受这些 该课程的头两年课程。核心课程 由高级生物化学的两个学期组成（生物化学101A＆ 101b），晚期有机合成的一个学期（化学134），一个学期 分子生物学学期（生物学105），机械学的一个学期 有机化学（从化学131、133或生物化学中选择 202），一个学期学期的学期学期或 晶体学结构测定（从化学132中选择 229，或235），最后是一个选修 化学，生物化学，生物学或神经科学计划。 第一年 学生还在不同的实验室进行六个星期的轮换 在程序中。学生必须完成一半的轮换 集中于化学合成的问题。这可以通过 从化学系的教师实验室旋转或 在适当的情况下，在生物化学部的实验室中。一个 结果的书面报告和口头表现在最后给出 每个旋转。旋转的目的是两个倍。首先，是 让学生接触许多不同的教职员工，以促进 他们选择导师，并为他们提供不同的经验 科学问题的方法。其次，旋转是 确保我们所有学生的动手合成经验 科学职业。此外，学生参加研讨会和 期刊俱乐部在整个逗留期间。