ISOLATION OF BIPOLAR CELL RESPONSES IN THE MACAQUE ERG

这项研究有两个主要目标。 一是 描述双极细胞对灵长类闪光的贡献 在完全暗适应条件下的视网膜电图（ERG），以及 在稳定的适应背景下。 第二个目标是 使用隔离的双极电池组件来给我们提供有关 双极细胞在视觉信号处理中的作用。 为了 获得这种双极细胞反应的理解， 药理学分离将用于猕猴， 它的视网膜非常接近人类。对躁郁症的理解 细胞反应无论从临床还是基础科学上都很重要 的观点 在基本水平上，双极细胞显然发挥着 在视网膜信号处理中的重要作用，然而，由于 在哺乳动物中记录这些细胞的技术困难， 无法对其反应进行详细研究 特性.临床上，有直接和间接的原因， 在ERG中研究PH。 直接地，这个信息将是有价值的 在解释视网膜电图的变化，发生在疾病， 双极细胞本身，如先天性静止性夜盲症。 间接地，很好地了解PII的特征 组件将允许更好地评估视网膜病理学的影响 在ERG的其他成分上，起源于双极远端 细胞（来自受影响的光感受器的a波，例如，视网膜炎 色素沉着），或接近双极细胞（振荡电位， 来自受影响的无长突细胞或神经节细胞的暗视阈值反应， 例如糖尿病性视网膜病、青光眼或视神经炎）。

There are two major goals of this research. The first is to characterize the bipolar cell contribution to the primate flash electroretinogram (ERG) under both fully dark-adapted conditions, and in the presence of steady adapting backgrounds. The second goal is to use the isolated bipolar cell component to give us information about the role that bipolar cells play in visual signal processing. In order to obtain this understanding of bipolar cell responses, the technique of pharmacological isolation will be used in macaque monkeys, an animal whose retina is very close to that of man. An understanding of bipolar cell responses is important from both a clinical and a basic science point of view. At a basic level, bipolar cells clearly play an important role in retinal signal processing, and yet, because of the technical difficulties of recording form such cells in mammals, it has not been possible to carry out detailed studies of their response properties. Clinically, there are direct and indirect reasons for studying PH in the ERG. Directly, this information would be valuable in interpreting changes in the ERG that occur in diseases that involve bipolar cells themselves, such as congenital stationary night blindness. Indirectly, a good understanding of the characteristics of the PII component would allow better assessment of effects of retinal pathology on other components of the ERG, originating either distal to the bipolar cells (a-wave from photoreceptors affected, for example, by retinitis pigmentosa), or proximal to the bipolar cells (oscillatory potentials, scotopic threshold response from amacrine or ganglion cells affected, for example, by diabetic retinopathy, glaucoma or optic neuritis).