SYSTEMIC ARTERIOPATHY IN SIV-INFECTED RHESUS MACAQUES (MACACA MULATTA)

感染 SIV 的恒河猴 (MACACA MULATTA) 的系统性动脉病

• 批准号: 7562385
• 负责人: ANDREW A LACKNER
• 金额: $ 7.16万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562385
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Antigens; Arterial Disorder; Blood Vessels; Body Weight decreased; Clinical; Computer Retrieval of Information on Scientific Projects Database; Cytomegalovirus; Cytomegalovirus Infections; Data; Diarrhea; Emaciation; Endothelial Cells; Enlargement of lymph nodes; Fibrosis; Funding; Grant; Heart; Hemorrhage; Histologic; Infarction; Institution; Intestines; Kidney; Lesion; Liver; Lymphatic Diseases; Macaca mulatta; Mitral Valve; Nuclear Inclusion; Nucleic Acids; Organ; Pancreas; Research; Research Personnel; Resources; SIV; Source; Spleen; Testis; United States National Institutes of Health; Vasculitis; lymph nodes; venule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Severe disseminated vasculopathy was observed in two simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta). These animals developed clinical signs of AIDS, including lymphadenopathy, weight loss, diarrhea and collapse. Grossly, both animals showed emaciation, lymphadenopathy, vegetations on the mitral valve, renal infarcts and a dilated intestine; one animal had multifocal hemorrhages in multiple organs. Histologically, both cases had disseminated arteriopathy characterized by intimal thickening and fibrosis with varying degrees of vasculitis. The lesion was prominent in the kidney, intestine, pancreas, liver, heart, lymph nodes, spleen and testis. Occasional venules had intimal thickening. Both cases had cytomegalovirus (CMV) infection with intranuclear inclusions, CMV antigen and nucleic acid; some inclusions were observed in endothelial cells within some of the vascular lesions in one of the two. These data suggest that CMV caused the unusual lesions.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 严重的弥漫性血管病变观察到两个猴免疫缺陷病毒（SIV）感染的恒河猴（Macaca mulatta）。这些动物出现了艾滋病的临床症状，包括淋巴结病、体重减轻、腹泻和虚脱。大体上，两只动物均显示消瘦、淋巴结病、二尖瓣赘生物、肾梗死和肠扩张;一只动物在多个器官中出现多灶性血管扩张。组织学上，这两个病例都有以内膜增厚和纤维化为特征的弥散性动脉病，伴有不同程度的血管炎。肾脏、肠、胰腺、肝脏、心脏、淋巴结、脾脏和睾丸的病变较明显。偶见小静脉内膜增厚。两例患者均存在巨细胞病毒（CMV）感染，伴核内包涵体、CMV抗原和核酸;其中一例患者的一些血管病变内的内皮细胞中观察到一些包涵体。这些数据表明，CMV引起的不寻常的病变。