SYSTEMIC ARTERIOPATHY IN SIV-INFECTED RHESUS MACAQUES (MACACA MULATTA)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在两只感染SIV的恒河猴(猕猴)身上观察到严重的播散性血管病变。这些动物出现了艾滋病的临床症状，包括淋巴结病、体重减轻、腹泻和虚脱。大体上，两只动物都表现出消瘦、淋巴结病、二尖瓣上的赘生物、肾梗死和肠管扩张；一只动物有多个器官的多灶性出血。组织学上，两例均有播散性动脉病变，以内膜增厚和纤维化为特征，并伴有不同程度的脉管炎。病变以肾、肠、胰腺、肝、心、淋巴结、脾、睾丸多见。偶见小静脉内膜增厚。两例均有巨细胞病毒(CMV)感染，核内包涵体、CMV抗原和核酸；其中一例在部分血管病变内的内皮细胞内可见一些包涵体。这些数据表明，CMV引起了这些不寻常的病变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Severe disseminated vasculopathy was observed in two simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta). These animals developed clinical signs of AIDS, including lymphadenopathy, weight loss, diarrhea and collapse. Grossly, both animals showed emaciation, lymphadenopathy, vegetations on the mitral valve, renal infarcts and a dilated intestine; one animal had multifocal hemorrhages in multiple organs. Histologically, both cases had disseminated arteriopathy characterized by intimal thickening and fibrosis with varying degrees of vasculitis. The lesion was prominent in the kidney, intestine, pancreas, liver, heart, lymph nodes, spleen and testis. Occasional venules had intimal thickening. Both cases had cytomegalovirus (CMV) infection with intranuclear inclusions, CMV antigen and nucleic acid; some inclusions were observed in endothelial cells within some of the vascular lesions in one of the two. These data suggest that CMV caused the unusual lesions.