TISSUE SPECIFIC EFFECTS OF PROGESTINS

孕激素的组织特异性作用

• 批准号: 2770459
• 负责人: KATHRYN B HORWITZ
• 金额: $ 24.93万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2770459
• 关键词: antisense nucleic acid; cell type; cyclic AMP; dimer; genetic regulation; genetic regulatory element; genetic transcription; hormone inhibitor; hormone regulation /control mechanism; progesterone receptors; progestins; protein isoforms; second messengers; tissue /cell culture; transcription factor; transfection

DESCRIPTION (adapted from the applicant's abstract): The proposed studies address molecular mechanisms that may explain tissue-specific and gene- specific regulation by progestins. Aim 1 is to assess the functional differences between A- and B-receptors in breast and endometrial cells. Aim 2 is to investigate BUS (the B-upstream segment) as a third transcriptional activation domain unique to B-receptors. Finally, Aim 3 is to determine the mechanisms of TAF-3 action in the BUS segment.

描述（改编自申请人的摘要）： 研究解决了可能解释组织特异性的分子机制， 和孕激素的基因特异性调节。 目标1是评估 乳腺A受体和B受体之间的功能差异 子宫内膜细胞 目的2是研究总线（B上游段） 作为B受体特有的第三转录激活结构域。 最后，目的3是确定TAF-3在BUS中的作用机制。 片段