CONFERENCE ON NUCLEAR RECEPTOR GENE FAMILY

核受体基因家族会议

• 批准号: 2555795
• 负责人: KATHRYN B HORWITZ
• 金额: $ 2.66万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-21 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2555795
• 关键词: genetic regulatory element; hormone receptor; meeting /conference /symposium; retinoid binding proteins; steroid hormone receptor; transcription factor; travel; vitamin D receptors

The steroid, thyroid, retinoic acid PPAR and vitamin D receptors, plus a growing number of orphan receptors are members of a superfamily of nuclear proteins that regulate transcription. These receptors control, among other things, developmental processes, tissue-specific differentiation, the growth and death of normal and malignant cells, reproductive behavior and metabolic activity. They act directly by binding to the hormone response elements of target promoters, or indirectly, by mechanisms that include interactions with transcriptional coregulators, or cross-talk with other signaling pathways. Among the problems facing this field are the mechanisms of tissue-specific regulation; cell-cycling and cancer; interactions with coregulatory factors; transcriptional integration of cell surface/nuclear receptor signals; the regulatory role of chromatin; post-translational modifications of receptors and isoform-specific actions; mechanisms of antagonists; receptor and domain structure; the function of orphan receptors. The intent of this meeting is to bring together leading experts in this diverse field, joined by younger investigators and trainees entering the field. The program includes state-of-the-art plenary lectures plus poster sessions. Selected abstracts authored by junior attendees will be chosen prior to the conference date and scheduled for 10-minute oral presentations. Our goal is two fold: First, to nurture and extend the intellectual interactions fostered by previous Keystone Symposia conferences on this receptor family. Second, to create a venue at which students and fellows can orally present their data to the fully assembled group.

类固醇，甲状腺，视黄酸，过氧化物酶体增殖体激活受体和维生素D受体，加上 越来越多的孤儿受体是一个超家族的成员， 调节转录的核蛋白质。这些受体控制， 除其他外，发育过程，组织特异性 分化，正常和恶性细胞的生长和死亡， 生殖行为和代谢活动。 他们直接通过 与靶启动子的激素反应元件结合，或 间接地，通过包括与转录因子相互作用的机制， 辅调节因子，或与其他信号通路的串扰。 中 这一领域面临的问题是组织特异性的机制， 调节;细胞周期和癌症;与协同调节的相互作用 转录因子;细胞表面/核受体整合 信号;染色质调控;翻译后 受体和亚型特异性作用的修饰; 拮抗剂;受体和结构域结构;孤儿功能 受体。 这次会议的目的是汇集这方面的主要专家， 不同的领域，加入了年轻的调查人员和学员进入 领域 该计划包括国家的最先进的全会讲座加上 海报会议。 由初级与会者撰写的精选摘要将 在会议日期之前选择，并安排10分钟的口头发言 介绍。我们的目标有两个方面：第一，培育和扩大 由以前的Keystone研讨会促进的智力互动 关于这个受体家族的会议。 第二，创造一个场所， 学生和研究员可以口头提出他们的数据，以充分 集合组。