INTERACTIVE 4D VISUALIZATION OF CONGENITAL HEART DISEASE

描述(摘自申请摘要)：发展和临床 一系列新的心血管软件显示技术的测试 提出了磁共振成像(MRI)数据。这些努力是 预计将加强诊断过程，并促进目前 挑战儿童的治疗和患者管理的决定 严重的先天性心脏病。特别是，对发育不良的评估 左右心综合征和单室性心脏需要改进 可视化和功能量化工具，用于评估和 监控严重程度和功能状态。 该系统的初步设计已基本完成。的设计特点 该软件系统建立在可广泛获得最新改进的基础上 3-D渲染硬件和11年临床观察 第一年在调查现场进行心脏MRI检查的经验 在该项目中，可以交付临床可用的原型进行测试 和用户反馈，包括高度精简的图像数据流水线， 先进的当代用户界面和其他必不可少的功能 广泛的临床评估。 提出的动态3-D显示技术结合了最大限度的解剖学 可在多层心电触发的电影-MRI扫描中获得的信息 心脏，通过在正确的3-D中同时显示所有切片图像 动态的几何透视(一部循环的节拍电影 心脏)。用户可以实时操纵所显示的切片对象以 改进区域解剖的可视化，沿 即时剪切平面，并通过以下方式为其他观察者注释显示 突出显示感兴趣的3D区域。 拟议的工作包括(1)开发第一个原型，使用 广泛的预先存在的内部开发软件库，(2)临床 从项目第二年起对该技术进行评估，(3) 实施改进措施，包括量化和显示 基本心脏功能参数，包括血流动力学数据和 跟踪用户反馈，并添加有限的DICOM I/O功能。

DESCRIPTION (Taken from application abstract): Development and clinical testing of a new family of software display techniques for cardiovascular magnetic resonance imaging (MRI) data are proposed. These efforts are anticipated to enhance the diagnostic process and facilitate currently challenging decisions on therapy and patient management of children with severe congenital heart disease. In particular, assessment of hypoplastic left and right heart syndromes and univentricular heart require improved visualization and function quantification tools for evaluation and monitoring of severity and functional status. The initial design of the system is largely completed. Design features of the software system are footed on recent improvements in widely available 3-D rendering hardware and on observations made during 11 years of clinical experience with cardiac MRI at the investigation site During the first year of the project a clinically usable prototype can be delivered for testing and user feedback, including a highly streamlined image data pipeline, sophisticated contemporary user interface, and other features essential for extensive clinical evaluation. The proposed dynamic 3-D display technique combines a maximum of anatomical information available in a multi-slice ECG-triggered cine-MRI scan of the heart, by displaying all slice images simultaneously in correct 3-D geometric perspective in dynamic fashion (a cyclic movie of the beating heart). A user can manipulate in real-time the displayed slice objects to improve visualization of regional anatomy, generate reformatted views along cutting planes on-the-fly, and annotate the display for other observers by highlighting 3-D regions of interest. The proposed effort includes (1) development of first prototype using extensive preexisting in-house developed software libraries, (2) clinical evaluation of the technique from the second year of the project onwards, (3) implementation of enhancements including quantitation and display of essential cardiac function parameters including hemodynamic data and follow-up on user feedback, and adding limited DICOM I/O functionality.