NONINVASIVE NMR IMAGING OF HUMAN MYOCARDIAL ARCHITECTURE

人体心肌结构的无创核磁共振成像

• 批准号: 2714121
• 负责人: VAN J WEDEEN
• 金额: $ 22.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714121
• 关键词: biomechanics; biotechnology; body water; clinical research; diffusion; dogs; heart imaging /visualization /scanning; heart motion; histology; human subject; magnetic resonance imaging; myocardium; noninvasive diagnosis

DESCRIPTION (Adapted from Applicant's Abstract): The proposed research seeks to map the principal myocardial structural elements, myofibers and cleavage planes, using novel,noninvasive magnetic resonance imaging (MRI) methods. Cardiac mechanics is primarily the reflection of myocardial architecture, yet this architecture has been difficult to assess in the laboratory and impossible to assess in vivo. The investigators have developed a novel MRI methodology to map the architectonics of the myocardium based upon measurement of the anisotropic diffusion of myocardial water. In preliminary studies, they have shown that the orientations of these principal material anisotropies (fibers and cleavage planes) can be visualized ex vivo and in vivo using a real time stimulated echo MR technique with excellent correlation by histology. MRI methodology possess two overwhelming advantages compared with previous methods for the analysis of myocardial architecture. First, it is potentially synoptic, revealing the architecture of myocardial fibers and cleavage planes throughout the heart at the same time. Second, it is noninvasive: fully applicable to the living human subject and causing no distortion of the architecture it seeks to observe. The proposed research will validate the MR diffusion maps of myocardial architecture, using histology to establish the local correspondence between specific eigenvectors of the diffusion tensor and specific cytoarchitectonic features. A broad study of the phenomenon of diffusion measurement in a moving system, in vitro and in an isolated canine heart preparation, will then be performed. The key technical challenge addressed by this method is the detection of the microscopic motions of water molecules against the background of the vigorous macroscopic motion of the heart. The investigators will then investigate the feasibility of obtaining such data in the human subject, first optimizing acquisition strategy, next characterizing human myocardial architecture ex vivo with MRI, and last investigating the capacity of MRI to define human myocardial architecture in vivo. These measurements will afford an opportunity to address several classic questions about myocardial structure and function, and also provide a foundation for subsequent studies of cardiac pathophysiology.

描述（改编自申请人摘要）：拟议的研究 试图绘制主要的心肌结构元素，肌纤维和 解理面，使用新型无创磁共振成像（MRI） 方法. 心脏力学主要是心肌力学的反映 架构，但这种架构一直难以评估， 实验室和不可能在体内评估。 调查人员已 开发了一种新的MRI方法来绘制 基于测量心肌的各向异性扩散 水 在初步研究中，他们表明， 这些主要的材料各向异性（纤维和解理面）可以 使用真实的时间刺激回波MR进行体外和体内可视化 与组织学相关性良好的技术。 MRI方法学具有 与以往的分析方法相比， 心肌结构。 首先，它具有潜在的概括性， 心肌纤维的结构和整个分裂平面 心与此同时 其次，它是非侵入性的：完全适用于 活的人类主体，不会造成它所寻求的建筑的扭曲 观察 该研究将验证心肌MR弥散图的有效性 建筑，使用组织学来建立局部对应关系， 扩散张量的特定特征向量和特定的细胞结构 功能. 扩散测量现象的广泛研究， 运动系统，在体外和在离体犬心脏制备，将 然后执行。 该方法解决的关键技术挑战是 检测水分子的微观运动， 心脏剧烈宏观运动的背景。 的 然后，研究人员将调查获得这些数据的可行性， 在人类主体中，首先优化获取策略， 用MRI表征离体人心肌结构，最后 研究MRI在确定人类心肌结构方面的能力， vivo. 这些措施将提供一个机会，以解决几个 关于心肌结构和功能的经典问题，并提供 为随后的心脏病理生理学研究奠定了基础。