DIFFUSION SPECTRUM MRI OF STRUCTURAL CHANGES IN WHITE MATTER IN DEMENTIA

痴呆症中白质结构变化的扩散谱 MRI

• 批准号: 7957228
• 负责人: VAN J WEDEEN
• 金额: $ 8.79万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957228
• 关键词: Alzheimer' s Disease; Architecture; Computer Retrieval of Information on Scientific Projects Database; Data; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Fiber; Funding; Grant; Image; Imaging technology; Impaired cognition; Institution; Magnetic Resonance Imaging; Maps; Medial; Methods; Neurodegenerative Disorders; Population; Procedures; Research; Research Personnel; Resources; Source; Structure; Temporal Lobe; Testing; Translating; United States National Institutes of Health; base; human subject; tool; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project will develop and test tools based on advanced diffusion MRI methods of diffusion spectral imaging (DSI) to map structural changes in white matter architecture and connectivity in early Alzheimer's dementia. Using diffusion tensor MRI, CIND Investigator Dr. Y Zhang et. al. [Zhang 2007] have recently demonstrated that structural changes with the fibers of the cingulum bundle of the medial temporal lobe have potential as a specific early marker of Alzheimer's disease. The Aims of this section are: 1. Translate and optimize DSI technology for use in human subjects with cognitive impairment. 2. Devise robust procedures of data reduction and analysis to map the cingulum bundle and quantify it structural integrity. 3. Evaluate the capacity of DSI to differentiate normal from abnormal structure of the cingulum bundle and other major fiber tracts of the temporal lobe in the Alzheimer's population.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目将开发和测试基于扩散光谱成像（DSI）的先进扩散MRI方法的工具，以绘制早期阿尔茨海默氏痴呆症中白色物质结构和连接的结构变化。 使用扩散张量MRI，CIND研究者Dr. Y Zhang et.等人[Zhang 2007]最近证明内侧颞叶扣带束纤维的结构变化有可能作为阿尔茨海默病的特异性早期标志物。 本节的目的是： 1.翻译和优化DSI技术，以用于患有认知障碍的人类受试者。 2.设计强大的数据简化和分析程序，以绘制扣带束并量化其结构完整性。 3.评估DSI区分阿尔茨海默病患者颞叶扣带回束和其他主要纤维束正常与异常结构的能力。