ROLE OF CYTOKINES IN THE DEVELOPMENT OF MAIDS

描述（改编自申请人的摘要）小鼠获得 免疫缺陷综合症（MAIDS）是由有缺陷的小鼠引起的 白血病病毒。 MAIDS 的发展需要以下人员的存在 CD4 阳性 T 细胞和成熟 B 细胞。 一种无帮助的 MAIDs 病毒， 缺乏在体内产生传染性病毒的能力 致病的。 此外，病毒感染的 B 细胞刺激同基因 T 细胞 体外细胞。 这些结果强烈表明病毒具有免疫能力 系统相互作用而非病毒感染直接发挥作用 在 MAIDS 中发挥着关键作用。 MAIDS 的特点是发展 淋巴结病、多克隆 B 细胞活化、高丙种球蛋白血症 T 细胞和 B 细胞的严重免疫缺陷。 其中一些 症状与人类艾滋病相似。 最近的分析 展示了女佣和艾滋病毒感染所共有的其他特征 包括超抗原（T 细胞产生的细胞因子）的参与 和程序性淋巴细胞死亡。 这些发现表明， 尽管两种病毒之间存在根本差异，但其机制 病毒引起多种症状，尤其是免疫缺陷 在 T 细胞中，可能是共享的。 该研究的长期目标是 了解 MAIDS 病毒与免疫系统之间的相互作用 免疫缺陷的发展。 了解致病性 MAIDs 病毒的研究将有助于了解一般情况 逆转录病毒引起的疾病，包括人类的艾滋病毒感染。

DESCRIPTION (Adapted from the applicant's abstract) Murine acquired immunodeficiency syndrome (MAIDS) is caused by a defective murine leukemia virus. The development of the MAIDS requires the presence of CD4 positive T cells and mature B cells. A helper free MAIDs virus which lacks the capacity to produce infectious virus in vivo was shown to be pathogenic. Furthermore, virus infected B cells stimulated syngeneic T cells in vitro. These results strongly suggest that the virus immune system interaction rather than the direct effect of virus infection play a key role in MAIDS. MAIDS is characterized by a development of lymphoadenopathy, polyclonal B cell activation, hypergammaglobulinemia and profound immunodeficiency in both T and B cells. Some of these symptoms are similar to those found in human Aids. Recent analysis demonstrated additional features shared by MAIDs and HIV infection which include involvement of superantigen, the cytokines produced by T cells and programmed lymphocytes death. These findings indicate that, despite the fundamental difference between two viruses, the mechanisms by which virus induces a variety of symptoms, especially immunodeficiency in T cells, may be shared. The long term goal of the study is to understand the MAIDS virus - immune system interaction in the development of the imunodeficiency. Understanding of the pathogenicity of the MAIDs virus will contribute to the understanding of general retrovirus induced diseases, including HIV infection in man.