ROLE OF CYTOKINES IN THE DEVELOPMENT OF MAIDS

描述(改编自申请人的摘要)获得的小鼠 免疫缺陷综合症(女仆)是由缺陷的小鼠引起的 白血病病毒。女仆的成长需要有 CD4阳性T细胞和成熟B细胞。一种无帮手女佣病毒 在体内缺乏产生传染性病毒的能力被证明是 致病的。此外，病毒感染的B细胞刺激同基因T细胞 体外培养的细胞。这些结果强烈地表明，该病毒对 系统相互作用而不是病毒感染的直接影响 在女佣中扮演一个关键角色。《女仆》的特点是发展了 淋巴结病、多克隆B细胞活化、高丙种球蛋白血症 T细胞和B细胞都存在严重的免疫缺陷。其中一些 症状与人类艾滋病的症状相似。最近的分析 展示了女佣和艾滋病毒感染所共有的其他特征 包括超抗原的参与，T细胞产生的细胞因子 和程序性淋巴细胞死亡。这些发现表明， 尽管两种病毒之间存在根本差异，但其机制 引起各种症状的病毒，尤指免疫缺陷 在T细胞中，可能是共享的。这项研究的长期目标是 了解女佣病毒与免疫系统的相互作用 免疫缺乏症的发生。对致病性的认识 对女佣病毒的了解将有助于对一般 逆转录病毒引起的疾病，包括人类感染艾滋病毒。

DESCRIPTION (Adapted from the applicant's abstract) Murine acquired immunodeficiency syndrome (MAIDS) is caused by a defective murine leukemia virus. The development of the MAIDS requires the presence of CD4 positive T cells and mature B cells. A helper free MAIDs virus which lacks the capacity to produce infectious virus in vivo was shown to be pathogenic. Furthermore, virus infected B cells stimulated syngeneic T cells in vitro. These results strongly suggest that the virus immune system interaction rather than the direct effect of virus infection play a key role in MAIDS. MAIDS is characterized by a development of lymphoadenopathy, polyclonal B cell activation, hypergammaglobulinemia and profound immunodeficiency in both T and B cells. Some of these symptoms are similar to those found in human Aids. Recent analysis demonstrated additional features shared by MAIDs and HIV infection which include involvement of superantigen, the cytokines produced by T cells and programmed lymphocytes death. These findings indicate that, despite the fundamental difference between two viruses, the mechanisms by which virus induces a variety of symptoms, especially immunodeficiency in T cells, may be shared. The long term goal of the study is to understand the MAIDS virus - immune system interaction in the development of the imunodeficiency. Understanding of the pathogenicity of the MAIDs virus will contribute to the understanding of general retrovirus induced diseases, including HIV infection in man.