NEURAL BASIS OF VASCULAR HEAD PAIN

血管头痛综合征，如偏头痛，是最常见的 所有的医疗问题。然而，血管性头痛的神经基础是 知之甚少，极具争议性。当前关于生物多样性的研究现状 血管性头痛的机制主要集中在疼痛的作用上- 脑血管的敏感感觉神经支配 三叉神经。对这种感官作用的进一步理解 血管性头痛的通路受限于我们知识中的关键差距 与其感官特别相关的通路的那些特性 功能和伤害性信息的传递。为了 更好地了解血管性头痛的外周机制， 拟议的研究将描述初级大脑的生理特性。 支配大脑的主要血管的传入神经元 颅内硬脑膜。将使用单单元记录来研究 分级过程中硬脑膜初级传入神经元的放电活动 机械、热和化学血管刺激在麻醉中的应用 老鼠。将实施重复刺激范式来研究 由不同形式的血管刺激引起的敏化。这个 这些研究提供的信息将对进一步 血管性头痛的神经基础研究进展。

Vascular headache syndromes such as migraine are among the most common of all medical problems. However, the neural basis of vascular headache is poorly understood and highly controversial. Current research on the mechanisms of vascular headache has focused on the role of a pain- sensitive sensory innervation of cranial blood vessels that arises from the trigeminal nerve. Further understanding of the role of this sensory pathway in vascular head pain is limited by critical gaps in our knowledge of those properties of the pathway that relate specifically to its sensory function and the transmission of nociceptive information. In order to better understand the peripheral mechanisms of vascular head pain, the proposed studies will characterize the physiological properties of primary afferent neurons that innervate the major blood vessels of the intracranial dura. Single-unit recording will be used to study the discharge activity of dural primary afferent neurons during graded mechanical, thermal, and chemical vascular stimulation in anesthetized rats. Repeated stimulation paradigms will be carried out to investigate sensitization induced by different forms of vascular stimulation. The information provided by these studies will be critical for further progress in understanding the neural basis of vascular head pain.