RISK AND PREDICTORS OF INTRACTABLE EPILEPSY IN CHILDREN

儿童难治性癫痫的风险和预测因素

• 批准号: 2655471
• 负责人: Anne T. Berg
• 金额: $ 32.53万
• 依托单位: NORTHERN ILLINOIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-15 至 2001-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2655471
• 关键词: adolescence (12-20); child (0-11); clinical research; disease /disorder classification; disease /disorder etiology; disease /disorder proneness /risk; epilepsy; human subject; longitudinal human study; nervous system disorder epidemiology; pathologic process; prognosis; remission /regression

DESCRIPTION: (Adapted from the Applicant's Abstract). This application is to continue an ongoing community-based study of the risks and predictors of intractable epilepsy in a prospectively identified cohort of children with newly diagnosed epilepsy, recruited from offices of child neurologists in Connecticut. Information comes from medical record review, interviews and follow-up calls. The primary goals are to determine the probability and to identify predictors of intractable epilepsy and of remission. Epilepsy is a common disorder. Through the 1980's the estimated cumulative risk of childhood and adolescent epilepsy was about 1.0% with remission occurring to 70% to 80%. Despite overall high remission rates, a substantial minority, 10-20%, develop intractable epilepsy, a severe, chronic, disabling condition. There is almost no information about the risk or predictors of intractability children. This is especially important with the increasing use of epilepsy surgery in children which has occurred in the nearly complete absence of any information about prevention, prediction, and eventual remission (without surgery) of intractability. Very recent (1993-1994), population-based studies have reported 40-50% decreases in the incidence of childhood epilepsy, possibly secondary to changes in causes of epilepsy and also improvements in diagnosis with correct recognition of events that are often mistaken for, but which are not epilepsy. Consequently, what is diagnosed as epilepsy today may differ substantially from that in the past, and earlier studies may no longer be fully informative about epilepsy today. This study is unique because it has a primary focus on intractable epilepsy, and it will provide information about remission of childhood onset epilepsy at it is currently diagnosed and treated. Such information can be used to plan treatment strategies, identify high risk patients in whom aggressive approaches may be taken and who may be good candidates for clinical trials, to educate and counsel families, and to provide information to guide future research into causes, mechanisms, treatment, and ultimately even the prevention of some forms of epilepsy.

描述：（改编自申请人摘要）。 本申请是 继续进行一项以社区为基础的研究， 在一个前瞻性确定的患有癫痫的儿童队列中， 新诊断的癫痫，从儿童神经学家的办公室招募， 康涅狄格 信息来自病历审查、访谈和 后续电话。 主要目标是确定概率， 确定难治性癫痫和缓解的预测因素。 癫痫是一 常见的疾病 在20世纪80年代， 儿童和青少年癫痫约为1.0%， 百分之七十到八十 尽管总体缓解率很高，但有相当一部分人， 10- 20%，发展为顽固性癫痫，一种严重的，慢性的，致残的 条件 几乎没有关于风险或预测因素的信息， 难管教的孩子 这一点尤其重要， 儿童癫痫手术的使用已经发生在近 完全没有任何关于预防、预测和 最终缓解（无需手术）。 非常近期 （1993-1994年），基于人口的研究报告说， 儿童癫痫的发病率，可能继发于 癫痫和诊断的改善与正确认识 这些事件经常被误认为是癫痫，但不是癫痫。 因此，今天诊断为癫痫症的可能会有很大的不同 以前的研究可能不再完全 关于癫痫的知识 这项研究是独一无二的，因为它有一个 主要集中在难治性癫痫，它将提供信息， 目前诊断为儿童期癫痫发作缓解， 治疗。 这些信息可用于计划治疗策略， 识别可以采取积极方法的高风险患者， 他们可能是临床试验的好候选人， 家庭，并提供信息，以指导未来的研究原因， 机制，治疗，甚至最终预防某些形式的 癫痫