RISK FACTORS FOR FIRST AND RECURRENT FEBRILE CONVULSIONS

首次和复发性热性惊厥的危险因素

• 批准号: 3477845
• 负责人: Anne T. Berg
• 金额: $ 5.59万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-02 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3477845
• 关键词: anticonvulsants; disease /disorder prevention /control; disease /disorder proneness /risk; epidemiology; epilepsy; febrile seizure; gender difference; human subject; interview; longitudinal human study; medical records; preschool child (1-5); relapse /recurrence; sign /symptom

Febrile convulsions are the most common childhood seizure disorder, affecting 2-5% of children by age five, about 100,000 new cases per year. Many receive expensive and invasive diagnosis workups. A large proportion are also placed on anticonvulsant medication. Approximately 30% of those who experience a febrile convulsion will have one or more recurrences. Most studies have focused on the long-term consequences of febrile convulsions; however, very little is known about the immediate illnesses associated with febrile convulsions or other antecedents of febrile convulsions. In addition, few risk factors for recurrent febrile convulsions have been identified. The primary aims of the proposed study are to identify (1) immediate precipitants of febrile convulsions. (2) antecedent risk factors for febrile convulsions, and (3) risk factors for recurrent febrile convulsions. Where possible, the study will also examine: (4) correlates of known risk factors for subsequent epilepsy in an effort to help clarify the association between febrile convulsions and epilepsy, (5) an explanation for the excess sale risk among children with first febrile convulsions, and (6) characteristics of the convulsion and of the child's condition indicative of intracranial infections. The proposal is for a case-control study of first febrile convulsions and a one-year follow-up of cases for recurrent febrile convulsions. Cases and controls will be identified over a three- year period from among children seeking care at three Bronx hospitals. Information will be obtained through medical record review and interviews with the children's parents. The information obtained will (1) identify immediate precipitants of febrile convulsions as well as antecedent risk factors thus furthering our understanding of this very common childhood disorder, (2) identify some potentially preventable factors associated with febrile convulsions, and (3) identify predictors of recurrent febrile convulsions allowing better targeting of anticonvulsant prophylaxis. Results from this study also may help clarify the consistent associations between febrile convulsions and later epilepsy and indirectly provide some insights into the etiology of epilepsy.

热性惊厥是最常见的儿童癫痫发作障碍， 影响2-5%的五岁儿童，每年约有100，000例新病例 年 许多人接受昂贵和侵入性的诊断检查。 一 大部分人还服用抗惊厥药物。 大约30%的人谁经历了热性惊厥将 有一个或多个递归。 大多数研究都集中在 热性惊厥的长期后果;然而，很少 已知与发热相关的直接疾病 惊厥或其他热性惊厥的先兆。 在 此外，很少有复发性热性惊厥的危险因素， 被识别。 本研究的主要目的是确定（1） 热性惊厥的直接诱因。 (2)先行风险 热性惊厥的危险因素，和（3）复发的危险因素 高热惊厥 在可能的情况下，研究还将审查： (4)已知的癫痫风险因素的相关性 努力帮助澄清热性惊厥 和癫痫，（5）解释过度销售风险， 儿童首次热性惊厥，和（6）特点 抽搐和孩子的情况表明 颅内感染 该建议是一个病例对照研究的第一次发热 惊厥和一年随访的情况下，复发性发热 抽搐 病例和对照将在三个- 在三个布朗克斯寻求护理的儿童中， 医院的 信息将通过医疗记录获得 对孩子的父母进行审查和采访。 所获得的信息将（1）确定直接沉淀物 以及先前的危险因素， 加深我们对这个非常普通的童年的理解 （2）确定一些潜在的可预防因素 与热性惊厥相关，（3）确定预测因子 可以更好地针对 抗惊厥预防。 这项研究的结果也可能有所帮助 阐明热性惊厥与 后来的癫痫，并间接提供了一些见解， 癫痫的病因

项目成果

Febrile seizures and epilepsy: the contributions of epidemiology.

• DOI: 10.1111/j.1365-3016.1992.tb00756.x
• 发表时间: 1992-04-01
• 期刊: Paediatric and perinatal epidemiology
• 影响因子: 2.8
• 作者: Berg, A T