RETINA--THE CONTROL OF PHOTORECEPTOR CELL FATE

视网膜——感光细胞命运的控制

• 批准号: 2842224
• 负责人: ANDREW TOMLINSON
• 金额: $ 25.48万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2842224
• 关键词: Drosophilidae; alternatives to animals in research; biological signal transduction; cell differentiation; cellular polarity; color visions; compound eye; developmental genetics; developmental neurobiology; gene expression; genetic regulation; histogenesis; retina; visual photoreceptor

DESCRIPTION (Adapted from applicant's abstract): Patterning of the fly retina starts as the morphogenetic furrow sweeps through the eye imaginal disc. Successive waves of activation of the Ras pathway recruit the photoreceptors that form the ommatidia. However, the ommatidia are not all identical and later patterning events add at least two new features to the eye: one is to define the type of inner photoreceptors that are involved in detection of colored or polarized light. Another is to create chirality to the ommatidium that is essential for the correct projection pattern of the photoreceptors to the neural cartridges in the optic lobe. This new application offers to test the mechanisms underlying these two events and in particular the role of wnt's.

描述（改编自申请人的摘要）：果蝇视网膜的图案形成始于形态发生沟扫过眼睛的成虫盘。Ras通路的连续激活波募集形成小眼的光感受器。然而，小眼并不都是相同的，后来的图案化事件至少为眼睛增加了两个新特征：一个是定义参与检测彩色或偏振光的内部感光器的类型。另一种方法是使小眼产生手性，这对于光感受器向视叶中的神经盒的正确投射模式至关重要。这个新的应用程序提供了测试这两个事件背后的机制，特别是wnt的作用。