RETINA--THE CONTROL OF PHOTORECEPTOR CELL FATE

描述(改编自申请者的摘要)：苍蝇视网膜的图案开始于形态发生皱纹扫过眼睛的成像盘。RAS通路的连续激活波招募形成小眼的光感受器。然而，小眼并不都是相同的，后来的图案化事件至少给眼睛增加了两个新的特征：一个是定义参与检测彩色或偏振光的内部光感受器的类型。另一种方法是在小眼球上形成手性，这是光感受器正确投射到视叶神经盒所必需的。这一新的应用程序提供了测试这两个事件背后的机制，特别是WNT的作用。

DESCRIPTION (Adapted from applicant's abstract): Patterning of the fly retina starts as the morphogenetic furrow sweeps through the eye imaginal disc. Successive waves of activation of the Ras pathway recruit the photoreceptors that form the ommatidia. However, the ommatidia are not all identical and later patterning events add at least two new features to the eye: one is to define the type of inner photoreceptors that are involved in detection of colored or polarized light. Another is to create chirality to the ommatidium that is essential for the correct projection pattern of the photoreceptors to the neural cartridges in the optic lobe. This new application offers to test the mechanisms underlying these two events and in particular the role of wnt's.