CONFERENCE ON LIPID MEDIATORS

脂质介质会议

• 批准号: 2792557
• 负责人: KARL FRANK AUSTEN
• 金额: $ 0.15万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-23 至 2000-04-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2792557
• 关键词: eicosanoid metabolism; meeting /conference /symposium; travel

The products of arachidonic acid metabolism are central to the inflammatory processes in bronchial asthma (leukotrienes) and in rheumatoid arthritis (prostaglandins) along with a diverse array of other pathobiologic states and physiologic functions. The introduction of novel therapies to prevent the biosynthesis or receptor-mediated action of the cysteinyl leukotrienes and of novel therapy selective for the induced prostaglandin endoperoxide synthetase type 2 (PGHS-2) has uncovered disease-related polymorphisms, additional disease prevention targets such as intestinal malignancy, and efficacy with reduced toxicity. At the same time, the use of gene disruption technology in the mouse has helped to define the functions of particular arachidonic acid metabolic pathways. The meeting planned will define the current controversies and insights provided by specific interventions in the human and gene disruption in the mouse, while concentrating at the cellular and molecular level on a variety of central evolving issues. These include: a clarification of the function in various cells of the ten or more phospholipase A2 (PLA2) species derived from separate genes and the compartmentalization of a particular PLA2 to its linked function with a particular perinuclear membrane associated enzyme; the transcriptional regulation of key enzymes in the eicosanoid generating pathways; and studies of gene polymorphism in association with disease states. There will also be a focus on the receptor proteins that appear to interact with arachidonic acid metabolites in two ways - within the nucleus for transcriptional regulation and at the plasma membrane for signal transduction responses. The program will assume reasonable state-of-the-art knowledge and will focus on the further implications of that knowledge and on the unresolved issues, using molecular, cellular, transgenic, and clinical approaches.

花生四烯酸代谢的产物是 支气管哮喘的炎症过程（白三烯）和 类风湿性关节炎（类风湿性关节炎）沿着各种各样的 其他病理生物学状态和生理功能。 引入 新的治疗方法，以防止生物合成或受体介导的 半胱氨酰白三烯的作用和选择性治疗 诱导的前列腺素内过氧化物合成酶2型（PGHS-2）具有 发现疾病相关的多态性，额外的疾病预防 目标，如肠道恶性肿瘤，和疗效与减少 毒性 与此同时，利用基因破坏技术， 老鼠已经帮助确定了特定花生四烯酸的功能， 酸代谢途径。 计划中的会议将确定当前的 具体干预措施提供的意见和见解， 人类和基因破坏的小鼠，而集中在 细胞和分子水平上的各种中心不断发展的问题。 这些包括：阐明了在各种细胞中的功能， 10种或10种以上来源于不同基因磷脂酶A2（PLA 2） 以及特定PLA 2与其相关功能的区室化 与特定的核周膜相关酶; 类花生酸生成关键酶的转录调控 基因多态性与疾病的关系 states. 也将有一个重点的受体蛋白质， 以两种方式与花生四烯酸代谢物相互作用-在 细胞核负责转录调控，质膜负责 信号转导反应 该计划将假设合理的 国家的最先进的知识，并将重点放在进一步的影响， 这些知识和未解决的问题，使用分子， 细胞、转基因和临床方法。