TREATMENT OF MILD HYPERTENSION STUDY--DATA ANALYSIS

高血压影响着大约四分之一的美国成年人和单身人士 去初级保健诊所就诊的最常见的医疗条件 医生。高血压是冠心病的主要危险因素， 中风的危险因素。疾病的实际检测、治疗和控制 美国的高血压状况令人失望。只有大约三分之二的人 高血压患者知道自己的病情，只有一半得到了治疗，而且 只有大约20%的人可以通过保守的 清晰度(小于140/90毫米汞)。 这笔分析补助金将为新的分析和报告提供支持 关于轻度高血压的治疗研究(TOMHS)，一项双盲， I期(轻度)舒张期的随机、安慰剂对照研究 高血压。这项研究随机选择了902名年龄在45岁至69岁之间的男性和女性 安慰剂或五种有效药物疗法中的一种。全 参与者接受了旨在减肥的生活方式干预， 减少钠和酒精，增加体力活动。 参与者被跟踪了至少四个耳朵，每年一次 上座率超过92%。60%的参与者是男性 20%是非洲裔美国人。 对TOMHS数据的新分析将产生有价值的信息。数据 将被分析以支持代表新的8篇论文的发展 这项研究提出的问题和具体的分组分析。这些文件 将调查以下主题：1)观察到相关的副作用 研究药物和安慰剂；2]体力活动的影响 成分对血压和其他研究结果的影响；3] 在研究开始前服用降压药 而不是因为血压试验而开始治疗 控制力、功能状态和性功能；4]评估 心电图和超声心动图预测未来心血管疾病的能力 事件；5]评估与收缩压有关的心电图改变 接受高血压治疗时的表现；6]评估 人体测量与血压的关系；7] 评价非甾体类抗炎药对糖尿病患者的影响 血压反应；和8]评估患者的研究结果60 基线年龄或以上的参与者与更年轻的参与者相比。

Hypertension affects about one in four adult Americans and the single most common medical condition for clinic visits to primary care physicians. Hypertension is a major risk factor for CHD and the primary risk factor for stroke. The actual detection, treatment and control of hypertension in the U.S. is disappointing. Only about two thirds of hypertensives are aware of their condition, only half are treated, and only about 20 percent are adequately controlled using a conservative definition (less than 140/90 mm Hg). This analysis grant will provide support for new analyses and reports of the Treatment of Mild Hypertension Study (TOMHS), a double-blind, randomized, placebo-controlled study of Stage I (mild) diastolic hypertensives. The study randomized 902 men and women ages 45-69 years to either placebo or one of five active drug therapies. All participants received lifestyle intervention aimed at weight loss, sodium and alcohol reduction, and increase in physical activity. Participants were followed for a minimum of four ears with annual visit attendance exceeding 92 percent. Sixty percent of participants were men and 20 percent were African-American. New analyses of the TOMHS data would yield valuable information. Data will be analyzed to support the development of 8 papers representing new questions and specific subgroup analyses from this study. These papers will investigate the following topics: 1] side effects observed related to study drug and placebo; 2] the effects of the physical activity component on blood pressure and other study outcomes; 3] the effect of taking antihypertensive medications prior to the start of the study versus beginning them as a result of the trial on blood pressure control, functional status, and sexual functioning; 4] evaluate the ability of ECG and echocardiography to predict future cardiovascular events; 5] evaluate changes in ECG findings related to systolic performance while being treated for hypertension; 6] evaluation of the relationship of anthropometric measurements and blood pressure; 7] evaluate the effects of non-steroidal anti-inflammatory medications on blood pressure response; and 8] evaluate study outcomes in patients 60 years of age or older at baseline versus younger participants.