TREATMENT OF MILD HYPERTENSION STUDY--DATA ANALYSIS

轻度高血压的治疗研究--数据分析

• 批准号: 2901332
• 负责人: Richard Hugo Grimm
• 金额: $ 5.55万
• 依托单位: HENNEPIN HEALTHCARE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2901332
• 关键词: age difference; alcoholic beverage consumption; body physical activity; cardiovascular disorder chemotherapy; clinical research; dietary sodium; electrocardiography; human data; human therapy evaluation; hypertension; lifestyle; longitudinal human study; nutrition related tag; statistics /biometry; weight loss

Hypertension affects about one in four adult Americans and the single most common medical condition for clinic visits to primary care physicians. Hypertension is a major risk factor for CHD and the primary risk factor for stroke. The actual detection, treatment and control of hypertension in the U.S. is disappointing. Only about two thirds of hypertensives are aware of their condition, only half are treated, and only about 20 percent are adequately controlled using a conservative definition (less than 140/90 mm Hg). This analysis grant will provide support for new analyses and reports of the Treatment of Mild Hypertension Study (TOMHS), a double-blind, randomized, placebo-controlled study of Stage I (mild) diastolic hypertensives. The study randomized 902 men and women ages 45-69 years to either placebo or one of five active drug therapies. All participants received lifestyle intervention aimed at weight loss, sodium and alcohol reduction, and increase in physical activity. Participants were followed for a minimum of four ears with annual visit attendance exceeding 92 percent. Sixty percent of participants were men and 20 percent were African-American. New analyses of the TOMHS data would yield valuable information. Data will be analyzed to support the development of 8 papers representing new questions and specific subgroup analyses from this study. These papers will investigate the following topics: 1] side effects observed related to study drug and placebo; 2] the effects of the physical activity component on blood pressure and other study outcomes; 3] the effect of taking antihypertensive medications prior to the start of the study versus beginning them as a result of the trial on blood pressure control, functional status, and sexual functioning; 4] evaluate the ability of ECG and echocardiography to predict future cardiovascular events; 5] evaluate changes in ECG findings related to systolic performance while being treated for hypertension; 6] evaluation of the relationship of anthropometric measurements and blood pressure; 7] evaluate the effects of non-steroidal anti-inflammatory medications on blood pressure response; and 8] evaluate study outcomes in patients 60 years of age or older at baseline versus younger participants.

高血压影响大约四分之一的美国成年人， 最常见的医疗条件的诊所访问的初级保健 医生 高血压是冠心病的主要危险因素， 中风的危险因素。 实际检测、治疗和控制 美国的高血压令人失望。 只有大约三分之二的 高血压患者知道自己的病情，只有一半得到治疗， 只有大约20%的人使用保守的方法得到了充分的控制， 清晰度（小于140/90 mm Hg）。 这项分析赠款将为新的分析和报告提供支持 轻度高血压治疗研究（TOMHS），一项双盲， I期（轻度）舒张压的随机、安慰剂对照研究 高血压 该研究随机抽取了902名年龄在45-69岁之间的男性和女性 安慰剂或五种活性药物治疗之一。 所有 参与者接受了旨在减肥的生活方式干预， 减少钠和酒精，增加体力活动。 参与者每年随访至少四次 出席率超过92%。60%的参与者是男性 20%是非洲裔美国人。 对TOMHS数据的新分析将产生有价值的信息。数据 将进行分析，以支持8篇论文的发展， 本研究的问题和特定亚组分析。 这些论文 将研究以下主题：1]观察到的相关副作用 研究药物和安慰剂; 2]体力活动的影响 对血压和其他研究结果的影响; 3] 研究开始前服用抗高血压药物 而不是因为血压试验而开始服用 控制，功能状态和性功能; 4]评估 ECG和超声心动图预测未来心血管疾病的能力 事件; 5]评价与收缩压相关的ECG结果变化 治疗高血压时的表现; 6] 人体测量与血压的关系; 7] 评价非甾体类抗炎药对 血压反应;和8]评估患者的研究结果60 基线时年龄≥ 30岁的受试者与年轻受试者相比。