CTL ACTIVITY IN HIV1 INFECTED INDIVIDUALS IN INDIA

描述：(改编自调查员S摘要)：目标 本研究旨在研究人类免疫缺陷病毒(HIV-1)抗原诱导的CTL反应。 感染各种艾滋病毒毒株并居住在印度的个人。 FIRCA的提案将支持印度网站的参与费用 在HIVNet赞助的多中心CTL研究中。这项研究将 确定两种CTL检测方法的可靠性和可行性 在网络中。该项目的研究假设是一个 有效的艾滋病毒疫苗策略应包括诱导CTL反应 它们针对的是在多个 基因分型。这项FIRCA提案将提供额外的资源和 将技术转让给印度的Nari，以建立和记录能力 在现场进行CTL。

DESCRIPTION: (adapted from the investigator s abstract): The objective of this study is to characterize the CTL response to HIV-1 antigens in individuals who are infected with various HIV strains and residing in India. The FIRCA proposal will support the costs for the India site to participate in the multi-centered CTL study sponsored by HIVNET. The study will determine the reliability and feasibility of two CTL assays carried out within the network. The research hypothesis of the project is that an effective HIV vaccine strategy should include the induction of CTL responses that are directed against epitopes which are conserved within multiple genotypes. This FIRCA proposal will provide additional resources and technology transfer to NARI in India to establish and document the capacity to perform CTL on site.