HIV-TB Fogarty Research Training Program

描述(由申请人提供)：本提案建立在一个为期20年的Fogarty艾滋病国际培训和研究计划(AITRP)的成功基础上，该计划支持了印度浦那的机构艾滋病毒研究能力建设。自1992年以来，霍普金斯印度Fogarty AITRP已在霍普金斯大学培训了103名印度科学家，内容涉及广泛的流行病学和基础科学研究项目，其中99人(95%)返回印度应用他们的Fogarty研究培训。Fogarty AITRP直接导致在国家艾滋病研究所(Nari)和Byramjee Jeejeebhoy医学院(BJMC)建立了高效、成功和可持续的艾滋病毒研究项目。BJMC还参与了20年来由美国国立卫生研究院支持的持续艾滋病毒研究，现在是一个成熟的临床试验单位(CTU)。我们现在建议，在这一应用中，战略性地扩大北京医科大学在艾滋病毒-结核病流行病学、临床和实验室研究方面的机构研究能力和科学领导地位。艾滋病毒-结核病研究培训计划将由Bob Bollinger博士领导，他在过去20年中担任印度Fogarty AITRP主任。他将与BJMC医学部主任D.B.Kadam博士密切合作，Kadam博士将担任Fogarty艾滋病毒-结核病研究培训计划的协调员。针对北京医学中心初级和中级教师的3阶段博士后培训计划将包括战略性的短期和长期培训活动、有指导的研究项目、研究研讨会和在北京医学中心建立数据管理和生物统计学培训中心。在第一阶段(第1年和第2年)，10名BJMC教员(6名流行病学/临床研究和4名实验室实习生)将参加战略性短期培训活动。第一阶段的成功完成将为这10名教师提供竞争第二阶段培训(2-4年)的机会，其中将包括4个深入培训机会(2个有指导的公共卫生硕士学位课程和2个有指导的博士后实验室研究奖学金)。这4名第二阶段的教员培训人员将负责在第三阶段(第5年)建立北京医学会艾滋病毒-结核病研究领导小组，该领导小组将通过他们自己作为导师参与另外5名北京医科大学教员培训来展示可持续的机构能力。这一艾滋病毒-结核病培训计划的设计反映了过去20年来在印度机构研究能力建设方面吸取的重要经验教训。我们计划的影响还将通过经验丰富的培训咨询委员会(TAC)的领导、14名经验丰富的霍普金斯大学教师导师(包括2名驻浦那的全职霍普金斯大学教师)以及霍普金斯全球临床健康教育中心的远程学习基础设施和经验来优化。与我们之前的AITRP项目一样，该项目的成功将通过同行评议的出版物来展示，特别是由Fogarty学员撰写的手稿、拨款申请以及BJMC Fogarty领导团队对机构领导力和其他教职员工和学生的本地指导的展示。

DESCRIPTION (provided by applicant): This proposal builds upon the success of a 20-year, Fogarty AIDS International Training and Research Program (AITRP) that supported institutional HIV research capacity building in Pune, India. Since 1992, the Hopkins India Fogarty AITRP has trained 103 Indian scientists at Hopkins, in a wide range of epidemiology and basic science research programs, of whom 99 (95%) returned to India to apply their Fogarty research training. The Fogarty AITRP has led directly to the establishment of highly productive, successful and sustainable HIV research programs at the National AIDS Research Institute (NARI) and Byramjee Jeejeebhoy Medical College (BJMC). BJMC has also participated in 20 years of continuous HIV NIH-supported research and is now a well- established Clinical Trials Unit (CTU). We now propose, in this application, to strategically expand the institutional research capacity and scientific leadership at BJMC in HIV-TB epidemiology, clinical and laboratory research. The HIV-TB Research Training Program will be led by Dr. Bob Bollinger, the India Fogarty AITRP Director for the past two decades. He will work closely with Dr. D. B. Kadam, Head of the Department of Medicine at BJMC, who will be the Coordinator of the Fogarty HIV-TB Research Training Program. A 3 Phase post-doctoral training program for junior and midlevel BJMC faculty will include strategic short- and long-term training activities, mentored research projects, research workshops and establishment of a Data Management and Biostatistics Training Core at BJMC. During Phase I (Years 1 and 2) ten BJMC faculty (6 epidemiology/clinical research and 4 lab trainees) will participate in strategic short-term trainin activities. Successful completion of Phase I will provide these 10 faculty an opportunity to compete for Phase II training (Years 2-4), which will include 4 in-depth training opportunities (2 mentored MPH degree programs and 2 mentored postdoctoral laboratory research fellowships). These 4 Phase II faculty trainees will then be responsible establishing The BJMC HIV-TB Research Leadership Team during Phase III (Year 5), which will demonstrate sustainable institutional capacity through their own participation as mentors for 5 additional BJMC faculty trainees. The design of this HIV-TB training program reflects key lessons learned over the past 20 years about building institutional research capacity in India. The impact of our program will also be optimized by the leadership of a highly experienced Training Advisory Committee (TAC), by participation 14 experienced Hopkins faculty mentors, including 2 full-time Hopkins faculty based in Pune, as well as the distance learning infrastructure and experience of the Hopkins Center for Clinical Global Health Education. As with our prior AITRP program, success of this program will be demonstrated by peer-reviewed publications, particularly manuscripts first-authored manuscripts by Fogarty trainees, grant submissions and demonstration of institutional leadership and local mentorship of other faculty and students, by the BJMC Fogarty Leadership Team.