ACQUIRED TOLERANCE TO CARDIAC XENOGRAFT

对心脏异种移植的获得性耐受

• 批准号: 2824692
• 负责人: Muhammad M Mohiuddin
• 金额: $ 4.53万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2824692
• 关键词: heart transplantation; immune tolerance /unresponsiveness; laboratory mouse; laboratory rat; transplantation immunology; xenotransplantation

Although clinical cardiac transplantation is effective therapy for patients with end stage cardiac disease the current shortage of donor organs limits the efficacy of this treatment. One solution to the organ donor shortage is the use of animal organs for human transplantation (xenotransplantation). Presently the immunologic barrier to xenotransplantation preclude this as a viable alternative. In previous work in an animal model of allo-transplantation, immune tolerance has been produced by exposure of the recipient animal to allogeneic cells either at a time when the immune system is immature (fetal, neonatal) or by exposing a transiently immunosuppressed mature animal to antigen intrathymicaIly. This research plan seeks to extend these observations to a model of xenotransplantation using a rat donor and mouse recipient. This model is advantageous since the availability of molecular reagents allows study of the mouse immune system at the molecular level. The research plan mirrors previous work in the allotransplant model. The research will explore different methods of exposing the immature murine immune system to rat cells and the subsequent response to a vascularizedcardiac graft. In addition, pretreatment of adult murine recipients will be followed by exposure to donor cells and subsequent vascularized cardiac xenotransplantation.

虽然临床心脏移植是治疗

项目成果

Targeted left ventricular lead positioning to the site of latest activation in cardiac resynchronization therapy: a systematic review and meta-analysis.

• DOI: 10.1093/europace/euad267
• 发表时间: 2023-08-02
• 期刊: EUROPACE
• 影响因子: 6.1
• 作者: Fyenbo, Daniel Benjamin;Bjerre, Henrik Laurits;Frausing, Maria Hee Jung Park;Stephansen, Charlotte;Sommer, Anders;Borgquist, Rasmus;Bakos, Zoltan;Glikson, Michael;Milman, Anat;Beinart, Roy;Kockova, Radka;Sedlacek, Kamil;Wichterle, Dan;Saba, Samir;Jain, Sandeep;Shalaby, Alaa;Kronborg, Mads Brix;Nielsen, Jens Cosedis
• 通讯作者: Nielsen, Jens Cosedis

Multilineage bone marrow chimerism produces cellular and humoral tolerance in a mouse-to-rat cardiac xenograft.

多系骨髓嵌合在小鼠至大鼠心脏异种移植物中产生细胞和体液耐受。

• DOI: 10.1016/s0041-1345(00)01098-8
• 发表时间: 2000
• 期刊: Transplantation proceedings
• 影响因子: 0.9
• 作者: Mohiuddin,MM;Qian,X;Qin,Y;DiSesa,VJ
• 通讯作者: DiSesa,VJ

Partial deletion of donor T cells in the recipient thymus in fully xenogeneic mouse-to-rat chimeras.

在完全异种小鼠-大鼠嵌合体中，受体胸腺中供体 T 细胞的部分缺失。

• DOI: 10.1016/s0041-1345(00)01107-6
• 发表时间: 2000
• 期刊: Transplantation proceedings
• 影响因子: 0.9
• 作者: Mohiuddin,MM;Qian,X;Qin,Y;DiSesa,VJ
• 通讯作者: DiSesa,VJ

Avoidance of graft versus host disease by proper titration of cell and radiation dose in a mouse to rat xeno-chimera.

通过适当滴定小鼠与大鼠异种嵌合体中的细胞和辐射剂量，避免移植物抗宿主病。

• DOI: 10.1016/s0041-1345(00)01050-2
• 发表时间: 2000
• 期刊: Transplantation proceedings
• 影响因子: 0.9
• 作者: Mohiuddin,MM;Qian,X;Qin,Y;DiSesa,VJ
• 通讯作者: DiSesa,VJ

Induction of tolerance to an "untolerizable" strain by double-strain intrathymic inoculation in experimental rat cardiac transplantation.

在实验性大鼠心脏移植中通过双菌株胸腺内接种诱导对“不可耐受”菌株的耐受。

• DOI: 10.1016/s0041-1345(98)01795-3
• 发表时间: 1999
• 期刊: Transplantation proceedings
• 影响因子: 0.9
• 作者: Mohiuddin,MM;Yokoyama,H;Reiss,GR;DiSesa,VJ
• 通讯作者: DiSesa,VJ