TGF-B RECEPTOR ALTERATIONS AND PANCREAS CANCER

描述：本研究的长期目标是确定 胰腺癌中的TGF β RII受体（RII）。 失去应答 TGF β在胰腺癌中很常见，通常是由于 RII基因的表达。 本修订版中要检验的假设 RII表达的缺失是由ras介导的 基因的下调和功能性RII受体的缺乏 在胰腺癌的致瘤特性中起重要作用。 的 具体目标是：1）确定致癌ras抑制 RII表达和/或引起对TGF β生长抑制的抗性，和 2)确定RII在ras突变的肿瘤进展中的生物学作用 胰腺癌细胞

DESCRIPTION: The long term goal of this study is to determine the role of TGFbeta RII receptor (RII) in pancreatic cancer. Loss of response to TGFbeta appears common to pancreatic cancer, which is often caused by a loss of the RII gene expression. The hypothesis to be tested in this revised application is that the loss of RII expression is caused by ras-mediated down regulation of the gene and that lack of a functional RII receptor plays an important role in the tumorigenic properties of pancreatic cancers. The specific aims are 1) Determine the mechanism by which oncogenic ras inhibits RII expression and/or causes resistance to growth inhibition by TGFbeta, and 2) Determine the biological role of RII in tumor progression in ras-mutated pancreatic cancer cells.