HORMONES, LIFESTYLE, AND BREAST CANCER

激素、生活方式和乳腺癌

• 批准号: 2733210
• 负责人: LINDA TITUS-ERNSTOFF
• 金额: $ 8.53万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2733210
• 关键词: alcoholic beverage consumption; behavioral /social science research tag; body physical activity; body weight; breast neoplasms; cancer risk; clinical research; diet; estrogens; female; hormone therapy; human data; human subject; lifestyle; postmenopause; pregnancy loss; tobacco abuse; women's health

DESCRIPTION: (Adapted from Investigator's Abstract) The investigators propose to continue their consortium of population-based case-control studies to 1) investigate the relation between postmenopausal hormone therapy and breast cancer mortality, and 2) evaluate the relation between certain lifestyle factors, including weight change, physical activity, pregnancy termination, and breast cancer incidence. Several studies have suggested improved survival among women using estrogen preparations at the time of breast cancer diagnosis. The investigators will evaluate the relation between postmenopausal hormone therapy and breast cancer mortality, ascertained though state vital records and the National Death Index, among cases enrolled in our previous and ongoing collaborative breast cancer studies in Wisconsin, Massachusetts, and New Hampshire (1988-95). Of the nearly 13,000 cases enrolled, they estimate that a minimum of 2600 deaths will have occurred in postmenopausal women. Thus, they will have ample power to evaluate the effects of postmenopausal hormone therapy, and to assess potential interactions with alcohol use and obesity, which may influence endogenous hormone levels. In addition, the availability of extensive questionnaire information will allow exploration of the possible effects of other exposures, including smoking and dietary factors, on breast cancer mortality. To meet their second aim, they will enroll 9000 breast cancer cases aged 20-69 and a comparable number of controls in our respective states over a 3-year period. Cases will be identified through state tumor registries, and controls through state drivers license lists and Medicare beneficiary lists. The large sample size is necessary to evaluate study hypotheses since the associations of interest are modest and patterns of exposure infrequent, e.g., weight gain at specific ages and induced abortions prior to full term pregnancies. The investigators state that the proposed studies, based on an efficient, well-established mechanism for selecting and interviewing cases and controls, and analysis of existing population-based data on thousands of women with breast cancer, will provide timely new information on potentially modifiable lifestyle determinants of breast cancer incidence and survival, in a highly cost-effective manner.

描述：（改编自调查员摘要）调查员 建议继续开展基于人群的病例控制联盟 研究1）调查绝经后激素之间的关系 治疗和乳腺癌死亡率，2）评估之间的关系 某些生活方式因素，包括体重变化、体力活动、 妊娠终止和乳腺癌发病率。 多项研究已 建议使用雌激素制剂提高女性的生存率 乳腺癌诊断时间。 调查人员将评估 绝经后激素治疗与乳腺癌死亡率之间的关系， 通过国家生命记录和国家死亡指数确定，其中 参与我们之前和正在进行的乳腺癌合作的病例 在威斯康星州、马萨诸塞州和新罕布什尔州进行研究（1988-95）。 的 登记了近 13,000 例病例，他们估计至少有 2600 人死亡 会发生在绝经后的妇女身上。 这样，他们将拥有充足的 评估绝经后激素治疗效果的能力，并 评估与饮酒和肥胖的潜在相互作用，这可能 影响内源性激素水平。 此外，可用性 广泛的问卷信息将有助于探索可能的 其他暴露（包括吸烟和饮食因素）对乳房的影响 癌症死亡率。 为了实现第二个目标，他们将招募 9000 名乳房 年龄在 20-69 岁之间的癌症病例以及我们的同等数量的对照组 3年期间的各个州。 案件将通过 州肿瘤登记处，并通过州驾驶执照清单和 医疗保险受益人名单。 评估需要大样本量 研究假设，因为兴趣关联是适度的并且模式 不频繁接触的情况，例如特定年龄的体重增加和诱发的体重增加 足月妊娠前的堕胎。 调查人员表示， 拟议的研究基于有效、完善的机制 选择和访谈案例和对照，并分析现有的 基于人口的数千名乳腺癌女性数据将提供 关于可能改变的生活方式决定因素的及时新信息 以极具成本效益的方式研究乳腺癌的发病率和生存率。