ATYPICAL NEVI IN MELANOMA--A CASE-CONTROL STUDY

黑色素瘤中的非典型痣——病例对照研究

• 批准号: 2871843
• 负责人: LINDA TITUS-ERNSTOFF
• 金额: $ 32.04万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2871843
• 关键词: alcoholic beverage consumption; cancer prevention; cancer risk; clinical research; human population study; human subject; interview; longitudinal human study; melanoma; nevus; pathologic process; pigmentation; preneoplastic state; radiation sensitivity; self examination; skin disorder diagnosis; solar radiation

Despite substantial interest in atypical nevi as melanoma risk factors and precursors, little is known about risk factors for these lesions, or their role in melanoma etiology. Previous case-control studies that have assessed atypical nevi as melanoma risk factors were small and/or clinic based. Similarly, only a few small, clinic-based studies have examined risk factors for atypical nevi. Our primary aims are to 1) conduct a large, population-based, case-control study of nonfamilial melanoma to evaluate atypical nevi, benign nevi, sun sensitivity, and solar exposure as risk factors, and 2) conduct a large, population-based evaluation of risk factors for atypical nevi. In separate analyses, we will explore risk factors associated with melanoma subgroups based on a) presence or absence of atypical nevi, and b) tumor histologic type. As a tertiary aim, we propose a validation substudy that will evaluate whether subjects can accurately self-diagnose atypical nevi. At least 535 cases of melanoma, ascertained through the NH State Cancer Registry, will be enrolled over a five year study period. We will enroll 800 population controls identified from drivers' license lists (age 65 or less), and medicare beneficiary lists (age greater than 65). Consenting subjects will complete a telephone interview, conduct skin self-examination, and participate in a dermatologist-conducted skin examination. Based on the dermatology examination, all subjects will be classified as "with" or "without" atypical nevi. Our statistical approach will include two primary case-control analyses to evaluate 1) risk factors for melanoma, and 2) risk factors for atypical nevi. In addition, we will conduct separate case-control comparisons to explore risk factors for specific melanoma subsets. Our approach will elucidate the etiology of melanoma, and identify risk factors for atypical nevi. Finally, we will evaluate subjects' ability to self-screen for atypical nevi by comparing the results of self-examination to the results of the dermatologist examination. The ability to self-diagnose atypical nevi has important implications for melanoma prevention.

尽管非典型痣作为黑色素瘤的危险因素引起了很大的兴趣 和前体，对这些病变的风险因素知之甚少，或 它们在黑色素瘤病因学中的作用。以前的病例对照研究， 被评估为黑色素瘤风险因素的非典型痣较小和/或临床 基于.同样，只有少数小型的、以临床为基础的研究检查了 非典型痣的危险因素我们的主要目标是：（1）开展 非家族性黑色素瘤大规模、基于人群的病例对照研究， 评估非典型痣、良性痣、太阳敏感性和日光暴露 作为风险因素，2）进行大规模的基于人群的评估， 非典型痣的危险因素在单独的分析中，我们将探讨 与黑色素瘤亚组相关的风险因素，基于a）存在或 无非典型痣，和B）肿瘤组织学类型。如叔 目的，我们提出了一个验证子研究，将评估是否受试者 能准确地自我诊断非典型痣。至少535例 黑色素瘤，通过NH国家癌症登记处确定，将是 参加了为期五年的研究。 我们将招收800人 从驾驶执照列表中识别的控制（65岁或以下），以及 医疗保险受益人名单（65岁以上）。 同意的受试者 将完成电话访谈，进行皮肤自我检查， 参加皮肤科医生进行的皮肤检查。基于 皮肤科检查，所有受试者将被分类为“有”或 没有非典型痣我们的统计方法将包括两个 主要病例对照分析以评价1）黑素瘤的风险因素， （2）非典型痣的危险因素。此外，我们还将 单独的病例对照比较，以探索特定 黑素瘤亚群。我们的方法将阐明黑色素瘤的病因， 并找出非典型痣的危险因素。最后，我们将评估 受试者自我筛查非典型痣的能力 自我检查的结果到皮肤科医生的结果 考试自我诊断非典型痣的能力具有重要的 黑色素瘤的预防