CIRRHOSIS AND ITS COMPLICATIONS

肝硬化及其并发症

• 批准号: 2885581
• 负责人: GUADALUPE GARCIA-TSAO
• 金额: $ 11.37万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2885581
• 关键词: ascites; cardiovascular shunt surgery; clinical research; clinical trials; health care cost /financing; hemorrhage; hospital utilization; human subject; human therapy evaluation; liver cirrhosis; liver failure; liver transplantation; medical complication; peritonitis; quality of life; thoracic surgery

The candidate, Dr. Guadalupe Garcia-Tsao, is Associate Professor in the Department of Internal Medicine at the Yale University School of Medicine. She has devoted her career to patient-oriented research (POR) in the area of cirrhosis and in complications. She has been involved in a wide range of POR, from descriptive studies to multicenter randomized clinical trials. Her studies in the area of varices, variceal hemorrhage, ascites and spontaneous bacterial peritonitis have made significant contributions to the management of patients with cirrhosis, the sixth leading cause of death in the United States in individuals between the ages of 25 and 65, the productive years of life. She is recognized as a clinical research in the area of portal hypertension as attested by invitations to chair abstract selection committees and to serve as session moderator at important scientific meetings, as well as invitations to write editorials, review articles and to become panel member at international consensus panels. Ascites is one of the main complications of cirrhosis and portal hypertension and Dr. Garcia-Tsao's short tem goals are to focus on this complication. One of these goals is to implement a randomized trial comparing the transjugular intrahepatic porto-systemic shunt with serial large-volume paracenteses in the treatment of patients with refractory ascites. This multicenter trial, partially funded by a VA Merit Review, will analyze not only differences in efficacy but also differences in quality of life and cost, and the results can potentially change current standards of care for patients with cirrhosis. R. Garcia-Tsao's long-term career goals are to continue to perform POR focused on prophylactic therapy and identification of prognostic factors in chronic liver disease as well as furthering her training in health services research. Dr. Garcia-Tsao has devoted a great deal of effort toward mentoring beginning clinical investigators in POR, especially in her capacity as co-Director of the Liver Center's Clinical Core. Yale University is one of the major teaching and research institutions of the United States and as such has well-established research and educational resources that will continue to be utilized by the candidate. The proposed award will allow her to carry out her research and mentoring objectives successful so that she can continue to make significant contributions in the field of cirrhosis and its complications.

候选人Guadalupe Garcia-Tsao博士是耶鲁大学医学院内科学系的副教授。她的职业生涯致力于以患者为导向的研究（POR），在肝硬化和并发症领域。从描述性研究到多中心随机临床试验，她参与了广泛的POR。她在静脉曲张，静脉曲张出血，腹水和自发性细菌性腹膜炎领域的研究为肝硬化患者的管理做出了重大贡献，肝硬化患者是美国25至65岁的个人的第六个主要死亡原因，即生产力的生产年。她被认为是门户高血压领域的临床研究，被邀请邀请主席摘要选择委员会主席，并在重要的科学会议上担任会议主持人，以及邀请函数，撰写社论，审查文章并成为国际共识小组的小组成员。腹水是肝硬化和门户高血压的主要并发症之一，Garcia-Tsao博士的短时间目标是专注于这种并发症。这些目标之一是实施一项随机试验，以比较肝内港口系统分流和连续大批量的子宫内的肝内港口 - 系统分流，以治疗难治性腹水的患者。该多中心试验部分由VA值得审查资助，不仅会分析疗效的差异，而且还将分析生活质量和成本的差异，结果可能会改变肝硬化患者的当前护理标准。 R. Garcia-Tsao的长期职业目标是继续致力于预防治疗和鉴定慢性肝病中预后因素，并促进她在卫生服务研究方面的培训。 Garcia-Tsao博士致力于指导POR的临床研究人员，尤其是她作为肝脏中心临床核心的联合导演的能力。耶鲁大学是美国的主要教学和研究机构之一，因此拥有良好的研究和教育资源，候选人将继续使用。拟议的奖项将使她能够实现自己的研究和指导目标，以便她可以继续在肝硬化及其并发症领域做出重大贡献。